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Tbio
ELL
RNA polymerase II elongation factor ELL

Protein Summary
Description
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262809
  • ENSP00000262809
  • ENSG00000105656

Symbol
  • C19orf17
  • MEN
  • ELL1
  • PPP1R68
  • C19orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.94
biological process
0.81
cellular component
0.75
pathway
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.25   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.25   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
EAF1
Tbio
Novelty:  0.81120425
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.99998586
p_ni:  0.00001414
Score:  0.996
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999948897
p_ni:  0.000051101
p_wrong:  1e-9
Data Source:  BioPlex
ELL3
Tbio
Family:  Enzyme
Novelty:  0.18245631
p_int:  0.999947429
p_ni:  0.000052571
Score:  0.986
Data Source:  BioPlex,STRINGDB
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.999831837
p_ni:  0.000168161
p_wrong:  1e-9
Score:  0.538
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999700969
p_ni:  0.000298972
p_wrong:  5.9e-8
Score:  0.463
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.998970293
p_ni:  0.001029706
p_wrong:  1e-9
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.997402667
p_ni:  0.002593933
p_wrong:  0.000003401
Score:  0.518
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.982727164
p_ni:  0.017262171
p_wrong:  0.000010665
Data Source:  BioPlex
EAF2
Tbio
Family:  TF
Novelty:  0.08392419
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
DNA Repair (R-HSA-73894)

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Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
4
6
7
99.3
mean corpuscular hemoglobin concentration
2
2
2
89.7
Oral ulcer
1
2
0
1.1
85
neutrophil percentage of leukocytes
2
2
2
84.2
neutrophil count
3
2
3
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
7
99.3
mean corpuscular hemoglobin concentration
2
89.7
Oral ulcer
0
1.1
85
neutrophil percentage of leukocytes
2
84.2
neutrophil count
3
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II elongation factor ELL
720221
Mouse
MGI:109377
13716
Rat
RGD:1311121
306347
Dog
elongation factor for RNA polymerase II
VGNC:40306
484820
Horse
elongation factor for RNA polymerase II
VGNC:17526
100070980
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II elongation factor ELL
Mouse
Rat
Dog
elongation factor for RNA polymerase II
Horse
elongation factor for RNA polymerase II
Publication Statistics
PubMed Score 246.25
PubMed score by year
PubTator Score 127.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title