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Tbio
ELF2
ETS-related transcription factor Elf-2

Protein Summary
Description
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Isoform 2 may function in repression of RUNX1-mediated transactivation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358635
  • ENSP00000351458
  • ENSG00000109381
  • ENST00000379549
  • ENSP00000368867
  • ENST00000379550
  • ENSP00000368868
  • ENST00000394235
  • ENSP00000377782
  • ENST00000510408
  • ENSP00000426997

Symbol
  • NERF
  • EU32
  • NERF
  • NERF-2
  • NERF-1A
  • NERF-1B
  • NERF-1a,b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
interacting protein
0.74
microRNA
0.66
kinase perturbation
0.6
tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.28   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.28   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999998977
p_ni:  0.000001023
Data Source:  BioPlex
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.999998377
p_ni:  0.000001623
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999994775
p_ni:  0.000005225
Data Source:  BioPlex
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.999994059
p_ni:  0.000005937
p_wrong:  4e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.999984681
p_ni:  0.000015317
p_wrong:  2e-9
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999865294
p_ni:  0.000134704
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.99882371
p_ni:  0.001176269
p_wrong:  2.1e-8
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.998793624
p_ni:  0.001164316
p_wrong:  0.000042059
Data Source:  BioPlex
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
p_int:  0.988162049
p_ni:  0.01155173
p_wrong:  0.000286221
Score:  0.158
Data Source:  BioPlex,STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.954
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in BCR signaling
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in BCR signaling
Transcriptional regulation by RUNX1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.6
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.6
11.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
E74 like ETS transcription factor 2
696760
Mouse
MGI:1916507
69257
Rat
RGD:1310585
361944
Dog
E74 like ETS transcription factor 2
VGNC:40299
476080
Horse
E74 like ETS transcription factor 2
VGNC:17519
100063399
Species
Name
OMA
EggNOG
Inparanoid
Macaque
E74 like ETS transcription factor 2
Mouse
Rat
Dog
E74 like ETS transcription factor 2
Horse
E74 like ETS transcription factor 2
Publication Statistics
PubMed Score 78.28
PubMed score by year
PubTator Score 42.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title