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Tbio
ELF2
ETS-related transcription factor Elf-2

Protein Summary
Description
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Isoform 2 may function in repression of RUNX1-mediated transactivation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358635
  • ENSP00000351458
  • ENSG00000109381
  • ENST00000379549
  • ENSP00000368867
  • ENST00000379550
  • ENSP00000368868
  • ENST00000394235
  • ENSP00000377782
  • ENST00000510408
  • ENSP00000426997

Symbol
  • NERF
  • EU32
  • NERF
  • NERF-2
  • NERF-1A
  • NERF-1B
  • NERF-1a,b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
interacting protein
0.74
microRNA
0.66
kinase perturbation
0.6
tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.75   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.75   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0