You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ELF1
ETS-related transcription factor Elf-1

Protein Summary
Description
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239882
  • ENSP00000239882
  • ENSG00000120690
  • ENST00000625359
  • ENSP00000486912

Symbol
  • RIA1
  • EFTUD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.79
molecular function
0.79
virus perturbation
0.72
PubMedID
0.69
transcription factor binding site profile
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.44   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.44   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.999999203
p_ni:  7.97e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.999992403
p_ni:  4.5e-8
p_wrong:  0.000007552
Data Source:  BioPlex
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.943
Data Source:  Reactome,STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.936
Data Source:  STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
Score:  0.917
Data Source:  Reactome,STRINGDB
E2F1
Tbio
Family:  TF
Novelty:  0.00277137
Score:  0.91
Data Source:  STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
Score:  0.905
Data Source:  STRINGDB
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
Score:  0.905
Data Source:  STRINGDB
E2F3
Tbio
Family:  TF
Novelty:  0.00287552
Score:  0.902
Data Source:  STRINGDB
E2F2
Tbio
Family:  TF
Novelty:  0.00418995
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in BCR signaling
Reactome
RUNX1 regulates transcription of genes involved in interleukin signaling
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in interleukin signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
81.8
lymphocyte count
4
2
4
81.5
lymphocyte percentage of leukocytes
2
2
2
80
neutrophil percentage of leukocytes
2
2
2
77.1
platelet crit
2
2
2
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
81.8
lymphocyte count
4
81.5
lymphocyte percentage of leukocytes
2
80
neutrophil percentage of leukocytes
2
77.1
platelet crit
2
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 1
VGNC:8875
452554
Macaque
E74 like ETS transcription factor 1
697952
Mouse
MGI:107180
13709
Rat
RGD:620697
85424
Dog
E74 like ETS transcription factor 1
VGNC:40298
476936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 1
Macaque
E74 like ETS transcription factor 1
Mouse
Rat
Dog
E74 like ETS transcription factor 1
Publication Statistics
PubMed Score 11.44
PubMed score by year
PubTator Score 77.34
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title