Protein Summary
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance. A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000359227
- ENSP00000352162
- ENSG00000196361
- ENST00000438662
- ENSP00000390878
- HUC
- PLE21
- HUC
- HUCL
- PLE21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.78 | ||
cellular component | 0.73 | ||
transcription factor binding site profile | 0.69 | ||
cell type or tissue | 0.65 | ||
PubMedID | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 649.12 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 161 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 649.12 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 161 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (150)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 2 | 2 | 2 | 89.5 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 76.5 | |||||
3 | 1 | 1 | 7.8 | 65.4 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 64.9 | |||||
Diuretic use measurement | 1 | 1 | 1 | 56.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 2 | 89.5 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 76.5 | |||||
1 | 7.8 | 65.4 | |||||
Calcium channel blocker use measurement | 1 | 64.9 | |||||
Diuretic use measurement | 1 | 56.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 3 | 746159 | ||||||
Mouse | MGI:109157 | 15571 | ||||||
Rat | RGD:628892 | 282824 | ||||||
Dog | ELAV like RNA binding protein 3 | VGNC:40297 | 484940 | |||||
Horse | ELAV like RNA binding protein 3 | VGNC:17516 | 100056901 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ELAV like RNA binding protein 3 | |||||
Horse | ELAV like RNA binding protein 3 | |||||
Publication Statistics
PubMed Score 649.12
PubMed score by year
PubTator Score 15.46
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
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0 of 0
PMID | Year | Title |
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