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Tchem
ELAVL3
ELAV-like protein 3

Protein Summary
Description
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance. A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359227
  • ENSP00000352162
  • ENSG00000196361
  • ENST00000438662
  • ENSP00000390878

Symbol
  • HUC
  • PLE21
  • HUC
  • HUCL
  • PLE21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.78
cellular component
0.73
transcription factor binding site profile
0.69
cell type or tissue
0.65
PubMedID
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (150)
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  1
Score:  0.489
Data Source:  BioPlex,STRINGDB
LGALS4
Tchem
Novelty:  0.00021923
Score:  0.923
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.843
Data Source:  STRINGDB
NEUROG1
Tbio
Family:  TF
Novelty:  0.00494095
Score:  0.782
Data Source:  STRINGDB
RBFOX3
Tbio
Novelty:  0.00038317
Score:  0.737
Data Source:  STRINGDB
DNAJC2
Tbio
Family:  TF
Novelty:  0.01515066
Score:  0.725
Data Source:  STRINGDB
L3MBTL1
Tchem
Family:  TF; Epigenetic
Novelty:  0.02321712
Score:  0.712
Data Source:  STRINGDB
ZPR1
Tbio
Novelty:  0.01893839
Score:  0.695
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.669
Data Source:  STRINGDB
RBFOX1
Tbio
Novelty:  0.00571285
Score:  0.662
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
89.5
Agents acting on the renin-angiotensin system use measurement
1
1
1
76.5
3
1
1
7.8
65.4
Calcium channel blocker use measurement
1
1
1
64.9
Diuretic use measurement
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
89.5
Agents acting on the renin-angiotensin system use measurement
1
76.5
1
7.8
65.4
Calcium channel blocker use measurement
1
64.9
Diuretic use measurement
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 3
746159
Mouse
MGI:109157
15571
Rat
RGD:628892
282824
Dog
ELAV like RNA binding protein 3
VGNC:40297
484940
Horse
ELAV like RNA binding protein 3
VGNC:17516
100056901
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 3
Mouse
Rat
Dog
ELAV like RNA binding protein 3
Horse
ELAV like RNA binding protein 3
Publication Statistics
PubMed Score 649.12
PubMed score by year
PubTator Score 15.46
PubTator score by year
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Related Publications
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PMID
Year
Title