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Tbio
ELAVL2
ELAV-like protein 2

Protein Summary
Description
Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223951
  • ENSP00000223951
  • ENSG00000107105
  • ENST00000380117
  • ENSP00000369460
  • ENST00000397312
  • ENSP00000380479
  • ENST00000544538
  • ENSP00000440998

Symbol
  • HUB
  • HUB
  • HELN1
  • HEL-N1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.97
transcription factor
0.75
PubMedID
0.73
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.57   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.57   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (336)
ELAVL3
Tchem
Novelty:  0.00143503
p_int:  1
Score:  0.489
Data Source:  BioPlex,STRINGDB
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999997497
p_ni:  0.000002503
Score:  0.513
Data Source:  BioPlex,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
p_int:  0.999979275
p_ni:  0.000020725
Data Source:  BioPlex
RBM45
Tbio
Novelty:  0.06739873
p_int:  0.999978518
p_ni:  0.000021482
Data Source:  BioPlex
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.999971777
p_ni:  0.000028053
p_wrong:  1.7e-7
Score:  0.711
Data Source:  BioPlex,STRINGDB
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.999967625
p_ni:  0.000032374
Data Source:  BioPlex
HNRNPCL1
Tdark
Novelty:  1.05199828
p_int:  0.999905728
p_ni:  0.000094272
Score:  0.168
Data Source:  BioPlex,STRINGDB
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.999838344
p_ni:  0.000161656
Data Source:  BioPlex
CDC40
Tbio
Novelty:  0.03139044
p_int:  0.999822828
p_ni:  0.000177171
p_wrong:  2e-9
Score:  0.909
Data Source:  BioPlex,STRINGDB
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.999816704
p_ni:  0.000183296
Score:  0.57
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
2
4
87.5
2
2
0
5.6
86.2
self reported educational attainment
2
2
2
81.3
cognitive function measurement
3
2
3
76.7
intelligence
3
10
1
5.9
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
87.5
0
5.6
86.2
self reported educational attainment
2
81.3
cognitive function measurement
3
76.7
intelligence
1
5.9
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 2
VGNC:14386
465023
Macaque
ELAV like RNA binding protein 2
708195
Mouse
MGI:1100887
15569
Rat
RGD:628611
286973
Dog
ELAV like RNA binding protein 2
VGNC:51712
481565
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 2
Macaque
ELAV like RNA binding protein 2
Mouse
Rat
Dog
ELAV like RNA binding protein 2
Publication Statistics
PubMed Score 231.57
PubMed score by year
PubTator Score 157.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title