Protein Summary
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZN ...more
- ENST00000407627
- ENSP00000385269
- ENSG00000066044
- ENST00000596459
- ENSP00000472197
- HUR
- HUR
- Hua
- MelG
- ELAV1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
protein complex | 0.99 | ||
hub protein | 0.95 | ||
biological term | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1049.58 (req: < 5)
Gene RIFs: 356 (req: <= 3)
Antibodies: 433 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1049.58 (req: >= 5)
Gene RIFs: 356 (req: > 3)
Antibodies: 433 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (500)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (22)
Reactome (6)
KEGG (2)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | HuR (ELAVL1) binds and stabilizes mRNA | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
Reactome | mRNA Splicing | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
HuR (ELAVL1) binds and stabilizes mRNA | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
mRNA Splicing | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (9)
Components (9)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 3 | 2 | 1 | 86.8 | |||||
CCL25 measurement | 1 | 1 | 1 | 81.9 | |||||
viral load | 1 | 1 | 1 | 71.6 | |||||
sex hormone-binding globulin measurement | 4 | 1 | 4 | 67.3 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1 | 86.8 | |||||
CCL25 measurement | 1 | 81.9 | |||||
viral load | 1 | 71.6 | |||||
sex hormone-binding globulin measurement | 4 | 67.3 | |||||
high density lipoprotein cholesterol measurement | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 1 | 743010 | ||||||
Macaque | ELAV like RNA binding protein 1 | 705806 | ||||||
Mouse | MGI:1100851 | 15568 | ||||||
Rat | RGD:1308649 | 363854 | ||||||
Dog | ELAV like RNA binding protein 1 | 611201 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 1 | |||||
Macaque | ELAV like RNA binding protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ELAV like RNA binding protein 1 | |||||
Publication Statistics
PubMed Score 1049.58
PubMed score by year
PubTator Score 507.00
PubTator score by year
Related Publications
Text Mined References (388)
GeneRif Annotations (356)
Items per page:
0 of 0
PMID | Year | Title |
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