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Tclin
ELANE
Neutrophil elastase

Protein Summary
Description
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263621
  • ENSP00000263621
  • ENSG00000197561
  • ENST00000590230
  • ENSP00000466090
  • ENST00000615489
  • ENSP00000480128
  • ENSG00000277571
  • ENST00000632488
  • ENSP00000488075

Symbol
  • ELA2
  • GE
  • NE
  • HLE
  • HNE
  • ELA2
  • SCN1
  • PMN-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.98
molecular function
0.9
cellular component
0.75
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3538.21   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3538.21   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1747
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1747)
Protein-Protein Interactions (304)
SLPI
Tbio
Family:  Enzyme
Novelty:  0.00194459
Score:  0.997
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.995
Data Source:  STRINGDB
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.987
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.982
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.982
Data Source:  STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.98
Data Source:  STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
Score:  0.979
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.977
Data Source:  STRINGDB
MMP8
Tchem
Family:  Enzyme
Novelty:  0.00105859
Score:  0.967
Data Source:  STRINGDB
GRN
Tbio
Novelty:  0.00096395
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Antimicrobial peptides
Reactome
Collagen degradation
Reactome
Complement cascade
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Antimicrobial peptides
Collagen degradation
Complement cascade
Degradation of the extracellular matrix
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
13
20
99.5
reticulocyte count
7
10
28
99.3
heel bone mineral density
3
4
6
94.5
serum gamma-glutamyl transferase measurement
2
2
3
93.1
hematocrit
2
2
3
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
20
99.5
reticulocyte count
28
99.3
heel bone mineral density
6
94.5
serum gamma-glutamyl transferase measurement
3
93.1
hematocrit
3
93.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elastase, neutrophil expressed
749897
Macaque
elastase, neutrophil expressed
106992354
Mouse
MGI:2679229
50701
Rat
RGD:1307968
299606
Dog
elastase, neutrophil expressed
442980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elastase, neutrophil expressed
Macaque
elastase, neutrophil expressed
Mouse
Rat
Dog
elastase, neutrophil expressed
Publication Statistics
PubMed Score 3538.21
PubMed score by year
PubTator Score 2220.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title