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Tbio
EIPR1
EARP and GARP complex-interacting protein 1

Protein Summary
Description
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382125
  • ENSP00000371559
  • ENSG00000032389

Symbol
  • TSSC1
  • TSSC1
  • EIPR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
VPS50
Tbio
Novelty:  0.17236696
p_int:  0.999999999
p_ni:  1e-9
Score:  0.949
Data Source:  BioPlex,STRINGDB
VPS54
Tbio
Novelty:  0.04428383
p_int:  0.999999967
p_ni:  3.2e-8
p_wrong:  1e-9
Score:  0.944
Data Source:  BioPlex,STRINGDB
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999999581
p_ni:  4.19e-7
Data Source:  BioPlex
VPS53
Tbio
Novelty:  0.07513165
p_int:  0.999999186
p_ni:  8.14e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
DHH
Tbio
Novelty:  0.00329784
p_int:  0.999998646
p_ni:  0.000001354
Score:  0.171
Data Source:  BioPlex,STRINGDB
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.999989719
p_ni:  0.000010281
Score:  0.747
Data Source:  BioPlex,STRINGDB
VPS51
Tbio
Novelty:  0.01766125
p_int:  0.999915907
p_ni:  0.000084093
Score:  0.965
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999649095
p_ni:  0.000350905
Score:  0.768
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.998913351
p_ni:  0.001086453
p_wrong:  1.96e-7
Score:  0.289
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.992211455
p_ni:  0.007079194
p_wrong:  0.000709351
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TPE interval measurement
1
1
1
21.5
response to exercise
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TPE interval measurement
1
21.5
response to exercise
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EARP complex and GARP complex interacting protein 1
VGNC:48965
743264
Mouse
MGI:1289332
380752
Dog
EARP complex and GARP complex interacting protein 1
VGNC:40295
475646
Horse
EARP complex and GARP complex interacting protein 1
VGNC:51298
100072854
Cow
EARP complex and GARP complex interacting protein 1
VGNC:28421
613935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EARP complex and GARP complex interacting protein 1
Mouse
Dog
EARP complex and GARP complex interacting protein 1
Horse
EARP complex and GARP complex interacting protein 1
Cow
EARP complex and GARP complex interacting protein 1
Publication Statistics
PubMed Score 14.50
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title