Tbio EIF5A Eukaryotic translation initiation factor 5A-1

Protein Summary

Description

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Uniprot Accession IDs

• P63241
• A8K9A0
• D3DTP2
• P10159
• Q16182
• Q7L7L3
• Q7Z4L1
• Q9D0G2
• eIF-5A-1

Gene Name

• EIF5A

Ensembl ID

• ENST00000336452
• ENSP00000336702
• ENSG00000132507
• ENST00000336458
• ENSP00000336776
• ENST00000416016
• ENSP00000396073
• ENST00000419711
• ENSP00000390677
• ENST00000571955
• ENSP00000458269
• ENST00000573542
• ENSP00000459611
• ENST00000576930
• ENSP00000459196

Symbol

• EIF-5A
• EIF5A1
• eIF5AI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
transcription factor	0.93
transcription factor binding site profile	0.92
kinase perturbation	0.88
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 5a-1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 5a-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.01   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.01   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0