Tbio EIF4G1 Eukaryotic translation initiation factor 4 gamma 1

Protein Summary

Description

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q04637
• D3DNT2
• D3DNT4
• D3DNT5
• E9PFM1
• G5E9S1
• O43177
• O95066
• Q5HYG0
• Q6ZN21
• Q8N102
• eIF-4-gamma 1

Gene Name

• EIF4G1

Ensembl ID

• ENST00000342981
• ENSP00000343450
• ENSG00000114867
• ENST00000346169
• ENSP00000316879
• ENST00000350481
• ENSP00000317600
• ENST00000352767
• ENSP00000338020
• ENST00000382330
• ENSP00000371767
• ENST00000392537
• ENSP00000376320
• ENST00000414031
• ENSP00000391935
• ENST00000424196
• ENSP00000416255
• ENST00000434061
• ENSP00000411826
• ENST00000435046
• ENSP00000404754

Symbol

• EIF4F
• EIF4G
• EIF4GI
• P220
• EIF4F
• EIF4G
• EIF4GI
• PARK18
• EIF-4G1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
kinase perturbation	1
disease perturbation	0.97
ligand (protein) perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.62   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 542   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.62   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (442)

Explore Interacting Targets

1 – 10 of 442

• See Interactions on String-DB

EIF4A1

Tchem

Novelty:  0.00269994

p_int:  0.999999309

p_ni:  6.91e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

EIF4E

Tchem

Novelty:  0.00072182

p_int:  0.999983917

p_ni:  0.000016083

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

IFT22

Tbio

Family:  Enzyme

Novelty:  0.18342877

p_int:  0.983894854

p_ni:  0.016105146

Data Source:  BioPlex

GCHFR

Tbio

Family:  Enzyme

Novelty:  0.04287433

p_int:  0.978821114

p_ni:  0.021178886

Score:  0.188

Data Source:  BioPlex,STRINGDB

EIF3I

Tbio

Novelty:  0.04398155

p_int:  0.957852466

p_ni:  0.042147534

Score:  0.981

Data Source:  BioPlex,STRINGDB

NFATC2IP

Tbio

Novelty:  0.02974299

p_int:  0.928115395

p_ni:  0.071884605

Score:  0.324

Data Source:  BioPlex,STRINGDB

EMILIN1

Tbio

Novelty:  0.02550566

p_int:  0.918104561

p_ni:  0.081895439

Data Source:  BioPlex

MAMDC2

Tdark

Novelty:  0.22933145

p_int:  0.780046337

p_ni:  0.219953663

Score:  0.29

Data Source:  BioPlex,STRINGDB

PABPC1

Tbio

Novelty:  0.00197523

Score:  0.999

Data Source:  Reactome,STRINGDB

EIF4B

Tbio

Novelty:  0.00665561

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (39)

Reactome (29)

KEGG (2)

PathwayCommons (4)

WikiPathways (4)

AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AUF1 (hnRNP D0) binds and destabilizes mRNA	56 targets	R-HSA-450408
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737

Name	Explore in Pharos	Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA	56 targets	R-HSA-450408
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (45)

Functions (9)

Components (6)

Processes (30)

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1 – 9 of 9

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
eukaryotic initiation factor 4E binding	Inferred from Direct Assay (IDA)	AgBase
mRNA binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
translation factor activity, RNA binding	Inferred from Mutant Phenotype (IMP)	ParkinsonsUK-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation initiation factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein-containing complex scaffold activity	Traceable Author Statement (TAS)	ParkinsonsUK-UCL
translation initiation factor binding	Traceable Author Statement (TAS)	ParkinsonsUK-UCL

Disease Associations ()

No disease associations found

GWAS Traits (19)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	2	9	12		99.5
platelet count	EFO_0004309	5	9	15		99.4
appendicular lean mass	EFO_0004980	4	2	4		92.2
hematological measurement	EFO_0004503	1	1	1		84.2
daytime rest measurement	EFO_0007828	1	1	1		74.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	12		99.5
platelet count	EFO_0004309	15		99.4
appendicular lean mass	EFO_0004980	4		92.2
hematological measurement	EFO_0004503	1		84.2
daytime rest measurement	EFO_0007828	1		74.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative initiation
Alternative splicing
Complete proteome
Disease mutation
Host-virus interaction
Initiation factor
Methylation
Neurodegeneration

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
alcohol consumption measurement
appendicular lean mass
birth weight
body mass index
cognitive function measurement
daytime rest measurement
hematological measurement
high density lipoprotein cholesterol measurement
intelligence

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 4 gamma 1	VGNC:7969	460888
Macaque	eukaryotic translation initiation factor 4 gamma 1		704923
Mouse	eukaryotic translation initiation factor 4, gamma 1	MGI:2384784	208643
Rat	eukaryotic translation initiation factor 4 gamma, 1	RGD:1306144	287986
Dog	eukaryotic translation initiation factor 4 gamma 1	VGNC:40289	100688785

Species	Name	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 4 gamma 1
Macaque	eukaryotic translation initiation factor 4 gamma 1
Mouse	eukaryotic translation initiation factor 4, gamma 1
Rat	eukaryotic translation initiation factor 4 gamma, 1
Dog	eukaryotic translation initiation factor 4 gamma 1

Publication Statistics

PubMed Score 566.62

PubMed score by year

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PubTator Score 526.65

PubTator score by year

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Related Publications

Text Mined References (169)

GeneRif Annotations (100)

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PMID	Year	Title