Tbio EIF4G1 Eukaryotic translation initiation factor 4 gamma 1

Protein Summary

Description

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q04637
• D3DNT2
• D3DNT4
• D3DNT5
• E9PFM1
• G5E9S1
• O43177
• O95066
• Q5HYG0
• Q6ZN21
• Q8N102
• eIF-4-gamma 1

Gene Name

• EIF4G1

Ensembl ID

• ENST00000342981
• ENSP00000343450
• ENSG00000114867
• ENST00000346169
• ENSP00000316879
• ENST00000350481
• ENSP00000317600
• ENST00000352767
• ENSP00000338020
• ENST00000382330
• ENSP00000371767
• ENST00000392537
• ENSP00000376320
• ENST00000414031
• ENSP00000391935
• ENST00000424196
• ENSP00000416255
• ENST00000434061
• ENSP00000411826
• ENST00000435046
• ENSP00000404754

Symbol

• EIF4F
• EIF4G
• EIF4GI
• P220
• EIF4F
• EIF4G
• EIF4GI
• PARK18
• EIF-4G1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
kinase perturbation	1
disease perturbation	0.97
ligand (protein) perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.79   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 542   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.79   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0