EIF4G1
Eukaryotic translation initiation factor 4 gamma 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
disease perturbation | 0.97 | ||
ligand (protein) perturbation | 0.96 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AUF1 (hnRNP D0) binds and destabilizes mRNA | ||||
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AUF1 (hnRNP D0) binds and destabilizes mRNA | ||||
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 9 | 12 | 99.5 | |||||
platelet count | 5 | 9 | 15 | 99.4 | |||||
appendicular lean mass | 4 | 2 | 4 | 92.2 | |||||
hematological measurement | 1 | 1 | 1 | 84.2 | |||||
daytime rest measurement | 1 | 1 | 1 | 74.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet crit | 12 | 99.5 | |||||
platelet count | 15 | 99.4 | |||||
appendicular lean mass | 4 | 92.2 | |||||
hematological measurement | 1 | 84.2 | |||||
daytime rest measurement | 1 | 74.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 4 gamma 1 | VGNC:7969 | 460888 | |||||
Macaque | eukaryotic translation initiation factor 4 gamma 1 | 704923 | ||||||
Mouse | MGI:2384784 | 208643 | ||||||
Rat | RGD:1306144 | 287986 | ||||||
Dog | eukaryotic translation initiation factor 4 gamma 1 | VGNC:40289 | 100688785 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 4 gamma 1 | |||||
Macaque | eukaryotic translation initiation factor 4 gamma 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 4 gamma 1 | |||||
PMID | Year | Title |
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