EIF4G1
Eukaryotic translation initiation factor 4 gamma 1
Protein Summary
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
- ENST00000342981
- ENSP00000343450
- ENSG00000114867
- ENST00000346169
- ENSP00000316879
- ENST00000350481
- ENSP00000317600
- ENST00000352767
- ENSP00000338020
- ENST00000382330
- ENSP00000371767
- ENST00000392537
- ENSP00000376320
- ENST00000414031
- ENSP00000391935
- ENST00000424196
- ENSP00000416255
- ENST00000434061
- ENSP00000411826
- ENST00000435046
- ENSP00000404754
- EIF4F
- EIF4G
- EIF4GI
- P220
- EIF4F
- EIF4G
- EIF4GI
- PARK18
- EIF-4G1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
disease perturbation | 0.97 | ||
ligand (protein) perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 628.79 (req: < 5)
Gene RIFs: 100 (req: <= 3)
Antibodies: 542 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 628.79 (req: >= 5)
Gene RIFs: 100 (req: > 3)
Antibodies: 542 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (442)
EIF4A1
Novelty: 0.00269994
p_int: 0.999999309
p_ni: 6.91e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4E
Novelty: 0.00072182
p_int: 0.999983917
p_ni: 0.000016083
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
IFT22
Family: Enzyme
Novelty: 0.18342877
p_int: 0.983894854
p_ni: 0.016105146
Data Source: BioPlex
GCHFR
Family: Enzyme
Novelty: 0.04287433
p_int: 0.978821114
p_ni: 0.021178886
Score: 0.188
Data Source: BioPlex,STRINGDB
EIF3I
Novelty: 0.04398155
p_int: 0.957852466
p_ni: 0.042147534
Score: 0.981
Data Source: BioPlex,STRINGDB
NFATC2IP
Novelty: 0.02974299
p_int: 0.928115395
p_ni: 0.071884605
Score: 0.324
Data Source: BioPlex,STRINGDB
MAMDC2
Novelty: 0.22933145
p_int: 0.780046337
p_ni: 0.219953663
Score: 0.29
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (39)
Reactome (29)
KEGG (2)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AUF1 (hnRNP D0) binds and destabilizes mRNA | ||||
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AUF1 (hnRNP D0) binds and destabilizes mRNA | ||||
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Viral Interactions (0)
Gene Ontology Terms (45)
Functions (9)
Components (6)
Processes (30)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 8 | 9 | 17 | 7.5 | 98.9 | ||||
appendicular lean mass | 4 | 2 | 4 | 93.2 | |||||
platelet crit | 2 | 9 | 12 | 92.2 | |||||
hematological measurement | 1 | 1 | 1 | 90.7 | |||||
daytime rest measurement | 1 | 1 | 1 | 86 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 17 | 7.5 | 98.9 | ||||
appendicular lean mass | 4 | 93.2 | |||||
platelet crit | 12 | 92.2 | |||||
hematological measurement | 1 | 90.7 | |||||
daytime rest measurement | 1 | 86 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 4 gamma 1 | VGNC:7969 | 460888 | |||||
Macaque | eukaryotic translation initiation factor 4 gamma 1 | 704923 | ||||||
Mouse | MGI:2384784 | 208643 | ||||||
Rat | RGD:1306144 | 287986 | ||||||
Dog | eukaryotic translation initiation factor 4 gamma 1 | VGNC:40289 | 100688785 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 4 gamma 1 | |||||
Macaque | eukaryotic translation initiation factor 4 gamma 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 4 gamma 1 | |||||
Publication Statistics
PubMed Score 628.79
PubMed score by year
PubTator Score 526.65
PubTator score by year
Related Publications
Text Mined References (169)
GeneRif Annotations (100)
Items per page:
0 of 0
PMID | Year | Title |
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