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Tbio
EIF4ENIF1
Eukaryotic translation initiation factor 4E transporter

Protein Summary
Description
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330125
  • ENSP00000328103
  • ENSG00000184708
  • ENST00000344710
  • ENSP00000342927
  • ENST00000397525
  • ENSP00000380659

Symbol
  • 4E-T
  • Clast4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
transcription factor binding site profile
0.91
virus perturbation
0.9
histone modification site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.999999955
p_ni:  2.1e-8
p_wrong:  2.4e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
p_int:  0.999999896
p_ni:  1.02e-7
p_wrong:  2e-9
Score:  0.977
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999755026
p_ni:  0.000244972
p_wrong:  2e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.995344354
p_ni:  0.004655641
p_wrong:  5e-9
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.971669495
p_ni:  0.026432193
p_wrong:  0.001898312
Score:  0.169
Data Source:  BioPlex,STRINGDB
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.863402741
p_ni:  0.13609124
p_wrong:  0.000506019
Score:  0.548
Data Source:  BioPlex,STRINGDB
LSM14A
Tbio
Novelty:  0.04728617
Score:  0.992
Data Source:  STRINGDB
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
Score:  0.991
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.983
Data Source:  STRINGDB
LSM14B
Tdark
Novelty:  0.31832554
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
1
3
74.2
myeloid white cell count
1
1
1
70.2
diet measurement
3
2
3
67.4
sum of basophil and neutrophil counts
1
1
1
29
body height
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
74.2
myeloid white cell count
1
70.2
diet measurement
3
67.4
sum of basophil and neutrophil counts
1
29
body height
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E nuclear import factor 1
VGNC:5257
107970226
Macaque
eukaryotic translation initiation factor 4E nuclear import factor 1
716871
Mouse
MGI:1921453
74203
Rat
RGD:1560908
305468
Dog
eukaryotic translation initiation factor 4E nuclear import factor 1
VGNC:40288
486366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E nuclear import factor 1
Macaque
eukaryotic translation initiation factor 4E nuclear import factor 1
Mouse
Rat
Dog
eukaryotic translation initiation factor 4E nuclear import factor 1
Publication Statistics
PubMed Score 25.98
PubMed score by year
PubTator Score 7.51
PubTator score by year
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Related Publications
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PMID
Year
Title