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Tbio
EIF4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

Protein Summary
Description
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation init ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373218
  • ENSP00000362314
  • ENSG00000148730

Symbol
  • 4EBP2
  • PHASII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
0.97
microRNA
0.83
co-expressed gene
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.78   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.78   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
EIF4E
Tchem
Novelty:  0.00072182
p_int:  0.999999701
p_ni:  4e-9
p_wrong:  2.95e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.999999289
p_ni:  7.09e-7
p_wrong:  1e-9
Score:  0.604
Data Source:  BioPlex,STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.985200231
p_ni:  0.006038371
p_wrong:  0.008761397
Score:  0.228
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
p_int:  0.985200231
p_ni:  0.006038371
p_wrong:  0.008761397
Score:  0.228
Data Source:  BioPlex,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.985
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.948
Data Source:  STRINGDB
EIF4E1B
Tdark
Novelty:  0.28023341
Score:  0.857
Data Source:  STRINGDB
MAPKAP1
Tbio
Novelty:  0.01301743
Score:  0.836
Data Source:  STRINGDB
EIF4EBP3
Tbio
Novelty:  0.12272754
Score:  0.809
Data Source:  STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 2
VGNC:12320
100610028
Macaque
eukaryotic translation initiation factor 4E binding protein 2
100424761
Mouse
MGI:109198
13688
Rat
RGD:1310824
361845
Dog
eukaryotic translation initiation factor 4E binding protein 2
VGNC:40287
489027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 2
Macaque
eukaryotic translation initiation factor 4E binding protein 2
Mouse
Rat
Dog
eukaryotic translation initiation factor 4E binding protein 2
Publication Statistics
PubMed Score 46.78
PubMed score by year
PubTator Score 30.50
PubTator score by year
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Related Publications
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PMID
Year
Title