Tbio EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1

Protein Summary

Description

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13541
• B2R502
• D3DSW8
• Q6IBN3
• 4E-BP1

Gene Name

• EIF4EBP1

Ensembl ID

• ENST00000338825
• ENSP00000340691
• ENSG00000187840

Symbol

• BP-1
• 4EBP1
• 4E-BP1
• PHAS-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	1
transcription factor perturbation	0.98
chemical	0.97
disease perturbation	0.95
biological term	0.93

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Eukaryotic Translation Initiation Factor 4e-binding Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Eukaryotic Translation Initiation Factor 4e-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.58   (req: < 5)

Gene RIFs: 178   (req: <= 3)

Antibodies: 1805   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.58   (req: >= 5)

Gene RIFs: 178   (req: > 3)

Antibodies: 1805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0