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Tdark
EIF4E1B
Eukaryotic translation initiation factor 4E type 1B

Protein Summary
Description
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318682
  • ENSP00000323714
  • ENSG00000175766
  • ENST00000504597
  • ENSP00000427633
  • ENST00000647833
  • ENSP00000497422
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
PubMedID
0.54
histone modification site profile
0.46
disease perturbation
0.43
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.972
Data Source:  STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.964
Data Source:  STRINGDB
EIF4G2
Tbio
Novelty:  0.01424739
Score:  0.956
Data Source:  STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
Score:  0.95
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.928
Data Source:  STRINGDB
EIF4ENIF1
Tbio
Novelty:  0.03835664
Score:  0.919
Data Source:  STRINGDB
NCBP2
Tbio
Novelty:  0.01426734
Score:  0.896
Data Source:  STRINGDB
EIF4EBP2
Tbio
Novelty:  0.01926413
Score:  0.857
Data Source:  STRINGDB
LSM14B
Tdark
Novelty:  0.31832554
Score:  0.844
Data Source:  STRINGDB
LSM1
Tbio
Novelty:  0.00962392
Score:  0.84
Data Source:  STRINGDB
Pathways (18)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
EGFR tyrosine kinase inhibitor resistance
KEGG
mTOR signaling pathway
KEGG
Longevity regulating pathway
KEGG
HIF-1 signaling pathway
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
EGFR tyrosine kinase inhibitor resistance
mTOR signaling pathway
Longevity regulating pathway
HIF-1 signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
56.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E family member 1B
VGNC:3974
462294
Macaque
eukaryotic translation initiation factor 4E family member 1B
703732
Mouse
MGI:2685119
218268
Dog
eukaryotic translation initiation factor 4E family member 1B
VGNC:40284
489099
Horse
eukaryotic translation initiation factor 4E family member 1B
VGNC:17503
100068758
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E family member 1B
Macaque
eukaryotic translation initiation factor 4E family member 1B
Mouse
Dog
eukaryotic translation initiation factor 4E family member 1B
Horse
eukaryotic translation initiation factor 4E family member 1B
Publication Statistics
PubMed Score 4.18
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title