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Tbio
EIF4B
Eukaryotic translation initiation factor 4B

Protein Summary
Description
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262056
  • ENSP00000262056
  • ENSG00000063046
  • ENST00000416762
  • ENSP00000412530

Symbol
  • EIF-4B
  • PRO1843
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.99
interacting protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.09   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 757   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.09   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0