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Tchem
EIF4A3
Eukaryotic initiation factor 4A-III

Protein Summary
Description
ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269349
  • ENSP00000269349
  • ENSG00000141543
  • ENST00000647795
  • ENSP00000497661
  • ENST00000649764
  • ENSP00000497641

Symbol
  • DDX48
  • KIAA0111
  • Fal1
  • RCPS
  • DDX48
  • MUK34
  • NUK34
  • NMP265
  • eIF4AIII
  • eIF4A-III
  • eIF-4A-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
kinase perturbation
0.97
protein complex
0.96
disease perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.32   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.32   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (632)
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999456105
p_ni:  0.000543894
Score:  0.188
Data Source:  BioPlex,STRINGDB
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  0.993032224
p_ni:  0.006967776
Score:  0.951
Data Source:  BioPlex,STRINGDB
CASC3
Tbio
Novelty:  0.03935581
p_int:  0.960879282
p_ni:  0.039120718
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.960689587
p_ni:  0.039310413
Score:  0.193
Data Source:  BioPlex,STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.940976219
p_ni:  0.059023781
Score:  0.246
Data Source:  BioPlex,STRINGDB
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.929131348
p_ni:  0.070868652
Data Source:  BioPlex
PNN
Tbio
Novelty:  0.01395394
p_int:  0.857631363
p_ni:  0.142368637
Score:  0.834
Data Source:  BioPlex,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.844377823
p_ni:  0.155622177
Data Source:  BioPlex
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.775205839
p_ni:  0.224794161
Score:  0.384
Data Source:  BioPlex,STRINGDB
SARNP
Tbio
Novelty:  0.00987312
p_int:  0.764923441
p_ni:  0.235076559
Score:  0.971
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Axon guidance
Cytokine Signaling in Immune system
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
5
87.4
reticulocyte count
7
2
9
87.3
mean reticulocyte volume
1
1
1
77.3
mean corpuscular volume
1
1
1
73
1
1
0
1.4
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
5
87.4
reticulocyte count
9
87.3
mean reticulocyte volume
1
77.3
mean corpuscular volume
1
73
0
1.4
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A3
VGNC:12113
454941
Macaque
eukaryotic translation initiation factor 4A3
712141
Mouse
MGI:1923731
192170
Rat
RGD:1591139
688288
Dog
eukaryotic translation initiation factor 4A3
VGNC:40281
475922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A3
Macaque
eukaryotic translation initiation factor 4A3
Mouse
Rat
Dog
eukaryotic translation initiation factor 4A3
Publication Statistics
PubMed Score 119.32
PubMed score by year
PubTator Score 65.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title