You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EIF4A2
Eukaryotic initiation factor 4A-II

Protein Summary
Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323963
  • ENSP00000326381
  • ENSG00000156976
  • ENST00000440191
  • ENSP00000398370

Symbol
  • DDX2B
  • EIF4F
  • DDX2B
  • EIF4A
  • EIF4F
  • BM-010
  • eIF4A-II
  • eIF-4A-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
molecular function
0.97
transcription factor binding site profile
0.94
interacting protein
0.93
cell type or tissue
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.56   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.56   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0