You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EIF3L
Eukaryotic translation initiation factor 3 subunit L

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381683
  • ENSP00000371099
  • ENSG00000100129
  • ENST00000624234
  • ENSP00000485663

Symbol
  • EIF3EIP
  • EIF3S6IP
  • EIF3EIP
  • EIF3S11
  • HSPC021
  • HSPC025
  • MSTP005
  • EIF3S6IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.95
interacting protein
0.88
transcription factor binding site profile
0.75
tissue
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
EIF3H
Tbio
Novelty:  0.02564681
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3CL
Tdark
Novelty:  0.15875888
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.999996182
p_ni:  0.000003818
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999992793
p_ni:  0.000007207
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRRC2B
Tdark
Novelty:  0.28608235
p_int:  0.999990737
p_ni:  0.000009263
Score:  0.811
Data Source:  BioPlex,STRINGDB
EIF3A
Tbio
Novelty:  0.00434615
p_int:  0.999973584
p_ni:  0.000026416
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3C
Tbio
Novelty:  0.02844331
p_int:  0.999967685
p_ni:  0.000032315
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3K
Tbio
Novelty:  0.04938688
p_int:  0.999958029
p_ni:  0.000041971
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
2
2
72.4
sex hormone-binding globulin measurement
4
2
4
69.8
cup-to-disc ratio measurement
2
2
2
67.9
heel bone mineral density
2
1
2
67.1
intraocular pressure measurement
4
3
5
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
72.4
sex hormone-binding globulin measurement
4
69.8
cup-to-disc ratio measurement
2
67.9
heel bone mineral density
2
67.1
intraocular pressure measurement
5
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit L
699189
Mouse
MGI:2386251
223691
Dog
eukaryotic translation initiation factor 3 subunit L
VGNC:40278
474513
Horse
eukaryotic translation initiation factor 3 subunit L
VGNC:17496
100054887
Cow
eukaryotic translation initiation factor 3 subunit L
VGNC:28402
514449
Species
Name
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit L
Mouse
Dog
eukaryotic translation initiation factor 3 subunit L
Horse
eukaryotic translation initiation factor 3 subunit L
Cow
eukaryotic translation initiation factor 3 subunit L
Publication Statistics
PubMed Score 8.72
PubMed score by year
PubTator Score 4.27
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title