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Tbio
EIF3I
Eukaryotic translation initiation factor 3 subunit I

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373586
  • ENSP00000362688
  • ENSG00000084623

Symbol
  • EIF3S2
  • TRIP1
  • TRIP1
  • EIF3S2
  • TRIP-1
  • PRO2242
  • eIF3-p36
  • eIF3-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
disease perturbation
0.93
histone modification site profile
0.91
virus perturbation
0.9
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (344)
EIF3H
Tbio
Novelty:  0.02564681
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3G
Tbio
Novelty:  0.04737601
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3CL
Tdark
Novelty:  0.15875888
p_int:  0.999999997
p_ni:  3e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRRC2B
Tdark
Novelty:  0.28608235
p_int:  0.99999989
p_ni:  1.1e-7
Score:  0.682
Data Source:  BioPlex,STRINGDB
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.999999582
p_ni:  4.18e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999998358
p_ni:  0.000001642
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3L
Tbio
Novelty:  0.11054104
p_int:  0.999996182
p_ni:  0.000003818
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3A
Tbio
Novelty:  0.00434615
p_int:  0.999989646
p_ni:  0.000010354
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3C
Tbio
Novelty:  0.02844331
p_int:  0.999975886
p_ni:  0.000024114
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit I
708145
Mouse
MGI:1860763
54709
Dog
eukaryotic translation initiation factor 3 subunit I
VGNC:40275
478152
Horse
eukaryotic translation initiation factor 3 subunit I
VGNC:17494
100070298
Cow
eukaryotic translation initiation factor 3 subunit I
VGNC:28399
521747
Species
Name
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit I
Mouse
Dog
eukaryotic translation initiation factor 3 subunit I
Horse
eukaryotic translation initiation factor 3 subunit I
Cow
eukaryotic translation initiation factor 3 subunit I
Publication Statistics
PubMed Score 23.55
PubMed score by year
PubTator Score 29.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title