EIF3E
Eukaryotic translation initiation factor 3 subunit E
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.93 | ||
virus perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Eukaryotic Translation Initiation | ||||
Reactome | Formation of a pool of free 40S subunits | ||||
Reactome | Formation of the ternary complex, and subsequently, the 43S complex | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Cap-dependent Translation Initiation | ||||
Eukaryotic Translation Initiation | ||||
Formation of a pool of free 40S subunits | ||||
Formation of the ternary complex, and subsequently, the 43S complex | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
balding measurement | 2 | 3 | 3 | 96.4 | |||||
1 | 5 | 5 | 93.2 | ||||||
1 | 2 | 2 | 86.6 | ||||||
Dupuytren Contracture | 2 | 1 | 0 | 1.3 | 80.6 | ||||
heel bone mineral density | 2 | 1 | 2 | 64.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
balding measurement | 3 | 96.4 | |||||
5 | 93.2 | ||||||
2 | 86.6 | ||||||
Dupuytren Contracture | 0 | 1.3 | 80.6 | ||||
heel bone mineral density | 2 | 64.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 3 subunit E | VGNC:6567 | 464336 | |||||
Macaque | eukaryotic translation initiation factor 3 subunit E | 697622 | ||||||
Mouse | MGI:99257 | 16341 | ||||||
Dog | eukaryotic translation initiation factor 3 subunit E | VGNC:40271 | 475070 | |||||
Horse | eukaryotic translation initiation factor 3 subunit E | VGNC:17491 | 100063841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 3 subunit E | |||||
Macaque | eukaryotic translation initiation factor 3 subunit E | |||||
Mouse | ||||||
Dog | eukaryotic translation initiation factor 3 subunit E | |||||
Horse | eukaryotic translation initiation factor 3 subunit E | |||||
PMID | Year | Title |
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