Tbio EIF3E Eukaryotic translation initiation factor 3 subunit E

Protein Summary

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).

Uniprot Accession IDs

• P60228
• O43902
• Q64058
• Q64059
• Q64252
• Q6FG33
• Q8WVK4
• eIF3e

Gene Name

• EIF3E

Ensembl ID

• ENST00000220849
• ENSP00000220849
• ENSG00000104408

Symbol

• EIF3S6
• INT6
• INT6
• EIF3S6
• EIF3-P48
• eIF3-p46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	0.93
virus perturbation	0.83
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit E

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit E

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.9   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.9   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (288)

Explore Interacting Targets

1 – 10 of 288

• See Interactions on String-DB

EIF3H

Tbio

Novelty:  0.02564681

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3M

Tbio

Novelty:  0.0174915

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3CL

Tdark

Novelty:  0.15875888

p_int:  0.999999995

p_ni:  5e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3L

Tbio

Novelty:  0.11054104

p_int:  0.999999989

p_ni:  1.1e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3F

Tbio

Novelty:  0.0319772

p_int:  0.999999911

p_ni:  8.9e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3I

Tbio

Novelty:  0.04398155

p_int:  0.999999582

p_ni:  4.18e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3G

Tbio

Novelty:  0.04737601

p_int:  0.999998216

p_ni:  0.000001784

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3A

Tbio

Novelty:  0.00434615

p_int:  0.999995496

p_ni:  0.000004504

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3C

Tbio

Novelty:  0.02844331

p_int:  0.999978771

p_ni:  0.000021229

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3B

Tbio

Novelty:  0.00889042

p_int:  0.999926807

p_ni:  0.000073193

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (11)

KEGG (2)

PathwayCommons (1)

WikiPathways (1)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Reactome	Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Reactome	Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (4)

Components (12)

Processes (7)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation initiation factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	2	3	3		97.3
Alopecia	Orphanet_79364	1	5	5		95.2
Dupuytren Contracture	EFO_0004229	2	1	0	1.3	93.6
androgenetic alopecia	EFO_0004191	1	2	2		92.8
heel bone mineral density	EFO_0009270	2	1	2		67.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	3		97.3
Alopecia	Orphanet_79364	5		95.2
Dupuytren Contracture	EFO_0004229	0	1.3	93.6
androgenetic alopecia	EFO_0004191	2		92.8
heel bone mineral density	EFO_0009270	2		67.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Initiation factor
Nucleus
Phosphoprotein
Polymorphism
Protein biosynthesis

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
androgenetic alopecia
balding measurement
brain volume measurement
Dupuytren Contracture
hair color
heel bone mineral density
IGF-1 measurement
ossification of the posterior longitudinal ligament of the spine

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 3 subunit E	VGNC:6567	464336
Macaque	eukaryotic translation initiation factor 3 subunit E		697622
Mouse	eukaryotic translation initiation factor 3, subunit E	MGI:99257	16341
Dog	eukaryotic translation initiation factor 3 subunit E	VGNC:40271	475070
Horse	eukaryotic translation initiation factor 3 subunit E	VGNC:17491	100063841

Species	Name	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 3 subunit E
Macaque	eukaryotic translation initiation factor 3 subunit E
Mouse	eukaryotic translation initiation factor 3, subunit E
Dog	eukaryotic translation initiation factor 3 subunit E
Horse	eukaryotic translation initiation factor 3 subunit E

Publication Statistics

PubMed Score 55.90

PubMed score by year

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PubTator Score 41.97

PubTator score by year

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Related Publications

Text Mined References (67)

GeneRif Annotations (24)

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PMID	Year	Title