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Tbio
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1

Protein Summary
Description
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of form ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256383
  • ENSP00000256383
  • ENSG00000134001
  • ENST00000466499
  • ENSP00000425299

Symbol
  • EIF2A
  • EIF2
  • EIF-2
  • EIF2A
  • EIF-2A
  • EIF-2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
kinase
0.92
virus perturbation
0.88
biological term
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1335.12   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1335.12   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (364)
EIF2S2
Tbio
Novelty:  0.0146918
p_int:  0.99980766
p_ni:  0.00019234
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF2AK4
Tchem
Family:  Kinase
Novelty:  0.00241683
Score:  0.999
Data Source:  STRINGDB
RPS8
Tbio
Novelty:  0.00976281
Score:  0.999
Data Source:  STRINGDB
EIF3B
Tbio
Novelty:  0.00889042
Score:  0.999
Data Source:  STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.999
Data Source:  STRINGDB
EIF2S3
Tbio
Novelty:  0.02055484
Score:  0.999
Data Source:  Reactome,STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.998
Data Source:  STRINGDB
EIF2AK1
Tchem
Family:  Kinase
Novelty:  0.01207075
Score:  0.998
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.998
Data Source:  STRINGDB
RPS12
Tbio
Novelty:  0.00497802
Score:  0.998
Data Source:  STRINGDB
Pathways (31)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of the ternary complex, and subsequently, the 43S complex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
40.6
reticulocyte count
4
1
4
30.2
body weight
1
1
1
14.2
sleep measurement
1
1
1
14.2
fasting blood insulin measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
40.6
reticulocyte count
4
30.2
body weight
1
14.2
sleep measurement
1
14.2
fasting blood insulin measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 subunit alpha
VGNC:3438
452980
Macaque
eukaryotic translation initiation factor 2 subunit alpha
710150
Mouse
MGI:95299
13665
Rat
RGD:620963
54318
Dog
eukaryotic translation initiation factor 2 subunit alpha
VGNC:40266
480361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 subunit alpha
Macaque
eukaryotic translation initiation factor 2 subunit alpha
Mouse
Rat
Dog
eukaryotic translation initiation factor 2 subunit alpha
Publication Statistics
PubMed Score 1335.12
PubMed score by year
PubTator Score 442.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title