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Tbio
EIF2D
Eukaryotic translation initiation factor 2D

Protein Summary
Description
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271764
  • ENSP00000271764
  • ENSG00000143486
  • ENST00000367114
  • ENSP00000356081

Symbol
  • HCA56
  • LGTN
  • LGTN
  • HCA56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
transcription factor perturbation
0.84
histone modification site profile
0.75
transcription factor
0.75
cell type or tissue
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999999266
p_ni:  6.72e-7
p_wrong:  6.2e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.983352705
p_ni:  0.016647034
p_wrong:  2.61e-7
Data Source:  BioPlex
EIF1
Tbio
Novelty:  0.00590381
Score:  0.979
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.95
Data Source:  STRINGDB
DENR
Tbio
Novelty:  0.00653432
Score:  0.949
Data Source:  STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.942
Data Source:  STRINGDB
RPS11
Tbio
Novelty:  0.0168881
Score:  0.942
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.941
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.941
Data Source:  STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
78.3
serum non-albumin protein measurement
1
1
1
57.3
mean corpuscular hemoglobin concentration
1
1
1
55.2
eosinophil percentage of leukocytes
1
1
1
54.4
eosinophil count
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
78.3
serum non-albumin protein measurement
1
57.3
mean corpuscular hemoglobin concentration
1
55.2
eosinophil percentage of leukocytes
1
54.4
eosinophil count
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2D
VGNC:528
457682
Macaque
eukaryotic translation initiation factor 2D
695274
Mouse
MGI:109342
16865
Rat
RGD:1561765
498225
Dog
eukaryotic translation initiation factor 2D
VGNC:40265
478951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2D
Macaque
eukaryotic translation initiation factor 2D
Mouse
Rat
Dog
eukaryotic translation initiation factor 2D
Publication Statistics
PubMed Score 30.39
PubMed score by year
PubTator Score 3.52
PubTator score by year
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Related Publications
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PMID
Year
Title