EIF2B3
Translation initiation factor eIF-2B subunit gamma
Protein Summary
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- ENST00000360403
- ENSP00000353575
- ENSG00000070785
- ENST00000372183
- ENSP00000361257
- ENST00000620860
- ENSP00000483996
- EIF-2B
- EIF2Bgamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
interacting protein | 0.79 | ||
histone modification site profile | 0.74 | ||
biological process | 0.68 | ||
tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.63 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.63 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
EIF2B5
Novelty: 0.0102209
p_int: 0.999997689
p_ni: 0.000002311
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF2B2
Novelty: 0.03253919
p_int: 0.999997448
p_ni: 0.000002552
Score: 0.999
Data Source: BioPlex,STRINGDB
GPR183
Family: GPCR
Novelty: 0.02005679
p_int: 0.99981029
p_ni: 0.00018971
Score: 0.185
Data Source: BioPlex,STRINGDB
NECTIN4
Novelty: 0.00694563
p_int: 0.996591015
p_ni: 0.003408985
Score: 0.596
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (5)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Eukaryotic Translation Initiation | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Recycling of eIF2:GDP | ||||
Reactome | Translation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cap-dependent Translation Initiation | ||||
Eukaryotic Translation Initiation | ||||
Metabolism of proteins | ||||
Recycling of eIF2:GDP | ||||
Translation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 1 | 1 | 0 | 7 | 54.4 | ||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 0 | 7 | 54.4 | ||||
BMI-adjusted hip circumference | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 2B subunit gamma | VGNC:7401 | 456543 | |||||
Macaque | eukaryotic translation initiation factor 2B subunit gamma | 705862 | ||||||
Mouse | MGI:1313286 | 108067 | ||||||
Rat | RGD:620821 | 171145 | ||||||
Dog | eukaryotic translation initiation factor 2B subunit gamma | VGNC:40262 | 475379 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 2B subunit gamma | |||||
Macaque | eukaryotic translation initiation factor 2B subunit gamma | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 2B subunit gamma | |||||
Publication Statistics
PubMed Score 21.63
PubMed score by year
PubTator Score 15.83
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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