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Tbio
EIF2A
Eukaryotic translation initiation factor 2A

Protein Summary
Description
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding diff ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406576
  • ENSP00000385292
  • ENSG00000144895
  • ENST00000460851
  • ENSP00000417229
  • ENST00000487799
  • ENSP00000420537

Symbol
  • CDA02
  • EIF-2A
  • MST089
  • MSTP004
  • MSTP089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.96
chemical
0.87
histone modification site profile
0.83
transcription factor binding site profile
0.75
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999991191
p_ni:  0.000008809
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999974843
p_ni:  0.000025156
p_wrong:  1e-9
Data Source:  BioPlex
TPH2
Tchem
Family:  Enzyme
Novelty:  0.00265377
p_int:  0.999854398
p_ni:  0.000144837
p_wrong:  7.65e-7
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.998143853
p_ni:  0.001614029
p_wrong:  0.000242118
Data Source:  BioPlex
SNX21
Tdark
Novelty:  0.32916633
p_int:  0.997102592
p_ni:  0.00158348
p_wrong:  0.001313927
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.996857114
p_ni:  0.001757229
p_wrong:  0.001385656
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.996755446
p_ni:  0.003032277
p_wrong:  0.000212276
Score:  0.183
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.996153484
p_ni:  0.003346636
p_wrong:  0.000499881
Data Source:  BioPlex
GML
Tdark
Novelty:  0.04982168
p_int:  0.99525506
p_ni:  0.003161702
p_wrong:  0.001583238
Data Source:  BioPlex
FGF9
Tbio
Novelty:  0.003428
p_int:  0.995043628
p_ni:  0.003481163
p_wrong:  0.001475209
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
IL6
PathwayCommons: pid
Ceramide signaling pathway
PathwayCommons: pid
TGF-beta receptor signaling
PathwayCommons: pid
Signaling events mediated by TCPTP
Name
Explore in Pharos
Explore in Source
IL6
Ceramide signaling pathway
TGF-beta receptor signaling
Signaling events mediated by TCPTP
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
63.7
1
1
0
1.3
33.1
waist circumference
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
63.7
0
1.3
33.1
waist circumference
1
4.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2A
VGNC:1803
470965
Macaque
eukaryotic translation initiation factor 2A
710497
Mouse
MGI:1098684
229317
Rat
RGD:1589591
502531
Dog
eukaryotic translation initiation factor 2A
VGNC:40255
477112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2A
Macaque
eukaryotic translation initiation factor 2A
Mouse
Rat
Dog
eukaryotic translation initiation factor 2A
Publication Statistics
PubMed Score 11.70
PubMed score by year
PubTator Score 415.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title