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Tdark
EIF1AD
Probable RNA-binding protein EIF1AD

Protein Summary
Description
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312234
  • ENSP00000309175
  • ENSG00000175376
  • ENST00000526451
  • ENSP00000436644
  • ENST00000527249
  • ENSP00000435439
  • ENST00000529964
  • ENSP00000435942
  • ENST00000533544
  • ENSP00000434056

Symbol
  • haponin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.91
transcription factor binding site profile
0.9
tissue sample
0.73
transcription factor
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
MTERF1
Tbio
Novelty:  0.00983613
p_int:  0.999999714
p_ni:  1e-9
p_wrong:  2.85e-7
Data Source:  BioPlex
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
p_int:  0.999983441
p_ni:  0.000016559
Data Source:  BioPlex
MAP4K5
Tchem
Family:  Kinase
Novelty:  0.04848162
p_int:  0.999973343
p_ni:  0.0000128
p_wrong:  0.000013858
Data Source:  BioPlex
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999969226
p_ni:  0.000030774
Data Source:  BioPlex
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999947717
p_ni:  0.000052232
p_wrong:  5.1e-8
Data Source:  BioPlex
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999931937
p_ni:  0.000068063
Data Source:  BioPlex
ISL2
Tbio
Family:  TF
Novelty:  0.03917372
p_int:  0.999916553
p_ni:  0.000045991
p_wrong:  0.000037456
Data Source:  BioPlex
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.999894352
p_ni:  0.000105307
p_wrong:  3.41e-7
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999881161
p_ni:  0.000118835
p_wrong:  4e-9
Data Source:  BioPlex
PSMC3IP
Tbio
Novelty:  0.06621408
p_int:  0.99984941
p_ni:  4.13e-7
p_wrong:  0.000150177
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
93.7
eosinophil percentage of leukocytes
2
2
2
91.6
uric acid measurement
2
2
2
89.6
sum of eosinophil and basophil counts
1
1
1
74.5
C-reactive protein measurement
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.7
eosinophil percentage of leukocytes
2
91.6
uric acid measurement
2
89.6
sum of eosinophil and basophil counts
1
74.5
C-reactive protein measurement
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 1A domain containing
VGNC:1048
451339
Macaque
eukaryotic translation initiation factor 1A domain containing
715063
Mouse
MGI:1917110
69860
Rat
RGD:1304686
293673
Dog
eukaryotic translation initiation factor 1A domain containing
VGNC:40254
476017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 1A domain containing
Macaque
eukaryotic translation initiation factor 1A domain containing
Mouse
Rat
Dog
eukaryotic translation initiation factor 1A domain containing
Publication Statistics
PubMed Score 4.58
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
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PMID
Year
Title