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Tdark
EID3
EP300-interacting inhibitor of differentiation 3

Protein Summary
Description
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000527879
  • ENSP00000435619
  • ENSG00000255150

Symbol
  • NS4EB
  • NSE4B
  • NSMCE4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.65
gene perturbation
0.62
tissue sample
0.59
cell type or tissue
0.53
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
NSMCE1
Tdark
Novelty:  0.75370409
p_int:  0.999999385
p_ni:  6.15e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
NSMCE3
Tbio
Novelty:  0.04335295
p_int:  0.999998267
p_ni:  0.000001733
Score:  0.994
Data Source:  BioPlex,STRINGDB
SMC5
Tbio
Novelty:  0.008623
p_int:  0.999997799
p_ni:  0.000002201
Score:  0.998
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
p_int:  0.999989449
p_ni:  0.000010551
Score:  0.996
Data Source:  BioPlex,STRINGDB
NSMCE2
Tbio
Family:  Enzyme
Novelty:  0.02320995
p_int:  0.997270196
p_ni:  0.00002852
p_wrong:  0.002701285
Score:  0.995
Data Source:  BioPlex,STRINGDB
SMDT1
Tbio
Novelty:  0.02448475
p_int:  0.996265815
p_ni:  0.003188026
p_wrong:  0.000546159
Score:  0.232
Data Source:  BioPlex,STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.919613801
p_ni:  0.080081445
p_wrong:  0.000304753
Score:  0.201
Data Source:  BioPlex,STRINGDB
TLK2
Tchem
Family:  Kinase
Novelty:  0.07082609
p_int:  0.898242108
p_ni:  0.101757891
p_wrong:  1e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
p_int:  0.814318645
p_ni:  0.185681355
Score:  0.201
Data Source:  BioPlex,STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.776016654
p_ni:  0.223983346
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

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1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 4.03
PubMed score by year
PubTator Score 3.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title