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Tbio
EID1
EP300-interacting inhibitor of differentiation 1

Protein Summary
Description
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530028
  • ENSP00000431162
  • ENSG00000255302

Symbol
  • C15orf3
  • CRI1
  • RBP21
  • CRI1
  • EID-1
  • RBP21
  • PTD014
  • C15orf3
  • PNAS-22
  • IRO45620
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.88
histone modification site profile
0.8
disease perturbation
0.74
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
UBB
Tbio
Novelty:  0.00661254
p_int:  0.99987759
p_ni:  0.00012241
Data Source:  BioPlex
FBXO21
Tbio
Novelty:  0.2186203
p_int:  0.999249417
p_ni:  0.000750581
p_wrong:  1e-9
Score:  0.576
Data Source:  BioPlex,STRINGDB
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.995545357
p_ni:  0.004454643
Data Source:  BioPlex
BDH2
Tbio
Family:  Enzyme
Novelty:  0.04118875
p_int:  0.987215012
p_ni:  0.012783009
p_wrong:  0.000001979
Score:  0.188
Data Source:  BioPlex,STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
p_int:  0.950230321
p_ni:  0.049769679
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
MYO9B
Tbio
Novelty:  0.0164265
p_int:  0.939520666
p_ni:  0.060479334
Score:  0.167
Data Source:  BioPlex,STRINGDB
MYO1D
Tbio
Novelty:  0.03263543
p_int:  0.908910823
p_ni:  0.091089177
Score:  0.392
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.877987008
p_ni:  0.122012964
p_wrong:  2.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.84056142
p_ni:  0.15943858
Score:  0.185
Data Source:  BioPlex,STRINGDB
MTPAP
Tbio
Family:  Enzyme
Novelty:  0.03447508
p_int:  0.771943522
p_ni:  0.228056469
p_wrong:  9e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
1
2
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
2
36.5
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EP300 interacting inhibitor of differentiation 1
VGNC:2488
744803
Mouse
MGI:1889651
58521
Rat
RGD:1562702
499882
Dog
EP300 interacting inhibitor of differentiation 1
VGNC:40252
608367
Cow
EP300 interacting inhibitor of differentiation 1
506056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EP300 interacting inhibitor of differentiation 1
Mouse
Rat
Dog
EP300 interacting inhibitor of differentiation 1
Cow
EP300 interacting inhibitor of differentiation 1
Publication Statistics
PubMed Score 44.12
PubMed score by year
PubTator Score 102.63
PubTator score by year
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Related Publications
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PMID
Year
Title