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Tchem
EHMT2
Histone-lysine N-methyltransferase EHMT2

Protein Summary
Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375530
  • ENSP00000364680
  • ENSG00000204371
  • ENST00000375537
  • ENSP00000364687
  • ENST00000383372
  • ENSP00000372863
  • ENSG00000206376
  • ENST00000383373
  • ENSP00000372864
  • ENST00000420336
  • ENSP00000396119
  • ENSG00000238134
  • ENST00000420874
  • ENSP00000411035
  • ENSG00000236759
  • ENST00000421926
  • ENSP00000416957
  • ENSG00000232045
  • ENST00000429506
  • ENSP00000406110
  • ENSG00000227333
  • ENST00000450075
  • ENSP00000392305
  • ENST00000450229
  • ENSP00000400838

Symbol
  • BAT8
  • C6orf30
  • G9A
  • KMT1C
  • NG36
  • G9A
  • BAT8
  • GAT8
  • NG36
  • KMT1C
  • C6orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.81
disease perturbation
0.74
drug perturbation
0.71
disease
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 247
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (247)
S-adenosylhomocysteine
Rendered image for S-adenosylhomocysteine
Ebselen
Rendered image for Ebselen
CHEMBL4872188,CHEMBL4850606
Rendered image for CHEMBL4872188,CHEMBL4850606
CHEMBL4865830
Rendered image for CHEMBL4865830
CHEMBL4873711,CHEMBL4872782
Rendered image for CHEMBL4873711,CHEMBL4872782
CHEMBL4854447
Rendered image for CHEMBL4854447
CHEMBL4855710
Rendered image for CHEMBL4855710
CHEMBL4856184
Rendered image for CHEMBL4856184
A-366
Rendered image for A-366
UNC0642
Rendered image for UNC0642
Protein-Protein Interactions (326)
XAGE2
Tbio
Novelty:  0.15338981
p_int:  0.999999554
p_ni:  4.23e-7
p_wrong:  2.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
XAGE3
Tdark
Novelty:  0.1418603
p_int:  0.999999043
p_ni:  9.47e-7
p_wrong:  9e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZNF462
Tbio
Novelty:  0.13731082
p_int:  0.999985685
p_ni:  0.000014314
p_wrong:  2e-9
Score:  0.579
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.999887522
p_ni:  0.000112477
p_wrong:  1e-9
Score:  0.251
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999822313
p_ni:  0.000177687
Data Source:  BioPlex
L3MBTL1
Tchem
Family:  TF; Epigenetic
Novelty:  0.02321712
p_int:  0.999421648
p_ni:  0.000578351
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
CDY2A
Tdark
Family:  Epigenetic
p_int:  0.993414304
p_ni:  0.006585667
p_wrong:  2.9e-8
Data Source:  BioPlex
ZNF223
Tdark
Family:  TF
Novelty:  0.78390275
p_int:  0.992019161
p_ni:  0.007978831
p_wrong:  0.000002009
Score:  0.241
Data Source:  BioPlex,STRINGDB
ZBTB46
Tbio
Family:  TF
Novelty:  0.04699856
p_int:  0.984154005
p_ni:  0.015845984
p_wrong:  1.1e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.984103725
p_ni:  0.015896092
p_wrong:  1.83e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (415)
Items per page:
1 – 5 of 415
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
9
0
1.9
99.7
9
9
0
1.9
99.7
9
9
0
1.9
99.7
9
9
0
1.9
99.7
9
9
0
1.9
99.7
Items per page:
1 – 5 of 415
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.7
0
1.9
99.7
0
1.9
99.7
0
1.9
99.7
0
1.9
99.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
euchromatic histone lysine methyltransferase 2
715824
Mouse
MGI:2148922
110147
Rat
RGD:1302972
361798
Dog
euchromatic histone lysine methyltransferase 2
VGNC:49100
474851
Horse
euchromatic histone lysine methyltransferase 2
VGNC:50590
100059118
Species
Name
OMA
EggNOG
Inparanoid
Macaque
euchromatic histone lysine methyltransferase 2
Mouse
Rat
Dog
euchromatic histone lysine methyltransferase 2
Horse
euchromatic histone lysine methyltransferase 2
Publication Statistics
PubMed Score 495.28
PubMed score by year
PubTator Score 174.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title