You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EHMT1
Histone-lysine N-methyltransferase EHMT1

Protein Summary
Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This act ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371394
  • ENSP00000485945
  • ENSG00000181090
  • ENST00000460843
  • ENSP00000417980
  • ENST00000462484
  • ENSP00000417328

Symbol
  • EUHMTASE1
  • GLP
  • KIAA1876
  • KMT1D
  • GLP
  • GLP1
  • KMT1D
  • KLEFS1
  • FP13812
  • EHMT1-IT1
  • EUHMTASE1
  • Eu-HMTase1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
molecular function
0.81
protein domain
0.73
histone modification site profile
0.72
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.25   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 483   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.25   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0