EGR3
Early growth response protein 3
Protein Summary
Probable transcription factor involved in muscle spindle development. This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
- ENST00000317216
- ENSP00000318057
- ENSG00000179388
- ENST00000522910
- ENSP00000430310
- PILOT
- EGR-3
- PILOT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
biological process | 0.94 | ||
small molecule perturbation | 0.93 | ||
PubMedID | 0.91 | ||
transcription factor binding site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.42 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 214 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.42 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 214 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
Nearest Tclin Targets
Pathways (7)
KEGG (3)
PathwayCommons (1)
WikiPathways (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | C-type lectin receptor signaling pathway | ||||
KEGG | Viral carcinogenesis | ||||
KEGG | Hepatitis B | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptor signaling pathway | ||||
Viral carcinogenesis | ||||
Hepatitis B | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (4)
Components (1)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 74.5 | |||||
glomerular filtration rate | 2 | 2 | 2 | 70.4 | |||||
creatinine measurement | 1 | 1 | 1 | 58.4 | |||||
hair color | 1 | 1 | 0 | 1.1 | 54.4 | ||||
2 | 2 | 2 | 50.6 | ||||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 74.5 | |||||
glomerular filtration rate | 2 | 70.4 | |||||
creatinine measurement | 1 | 58.4 | |||||
hair color | 0 | 1.1 | 54.4 | ||||
2 | 50.6 | ||||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | early growth response 3 | VGNC:11966 | 464048 | |||||
Mouse | MGI:1306780 | 13655 | ||||||
Rat | RGD:2545 | 25148 | ||||||
Dog | early growth response 3 | VGNC:40242 | 486121 | |||||
Horse | early growth response 3 | VGNC:17464 | 100057675 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | early growth response 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | early growth response 3 | |||||
Horse | early growth response 3 | |||||
Publication Statistics
PubMed Score 136.42
PubMed score by year
PubTator Score 84.42
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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