You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
EGLN3
Egl nine homolog 3

Protein Summary
Description
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250457
  • ENSP00000250457
  • ENSG00000129521

Symbol
  • PHD3
  • HIFPH3
  • HIFP4H3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.95
kinase perturbation
0.91
microRNA
0.83
biological process
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.16   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.16   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 112
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (158)
SBDS
Tbio
Novelty:  0.00818779
p_int:  0.999984597
p_ni:  0.000015403
Data Source:  BioPlex
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.993218455
p_ni:  0.006781544
p_wrong:  1e-9
Data Source:  BioPlex
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
p_int:  0.984992108
p_ni:  0.015007892
Data Source:  BioPlex
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.991
Data Source:  Reactome,STRINGDB
EPAS1
Tchem
Novelty:  0.00307448
Score:  0.983
Data Source:  Reactome,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
Score:  0.982
Data Source:  Reactome,STRINGDB
HIF3A
Tbio
Novelty:  0.01505965
Score:  0.976
Data Source:  Reactome,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.954
Data Source:  Reactome,STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.952
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.946
Data Source:  Reactome,STRINGDB
Pathways (31)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
4
90.8
hemoglobin measurement
2
3
3
89.1
ferritin measurement
1
1
1
82.7
intraocular pressure measurement
1
1
1
33.1
reasoning
1
1
0
1.7
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
90.8
hemoglobin measurement
3
89.1
ferritin measurement
1
82.7
intraocular pressure measurement
1
33.1
reasoning
0
1.7
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
egl-9 family hypoxia inducible factor 3
VGNC:10306
452850
Macaque
egl-9 family hypoxia inducible factor 3
717342
Mouse
MGI:1932288
112407
Rat
RGD:71019
54702
Dog
egl-9 family hypoxia inducible factor 3
VGNC:40241
480286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
egl-9 family hypoxia inducible factor 3
Macaque
egl-9 family hypoxia inducible factor 3
Mouse
Rat
Dog
egl-9 family hypoxia inducible factor 3
Publication Statistics
PubMed Score 170.16
PubMed score by year
PubTator Score 110.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title