Protein Summary
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limi ...more
- ENST00000250457
- ENSP00000250457
- ENSG00000129521
- PHD3
- HIFPH3
- HIFP4H3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
PubMedID | 0.95 | ||
kinase perturbation | 0.91 | ||
microRNA | 0.83 | ||
biological process | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.16 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 440 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.16 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 440 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 112
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (112)
Protein-Protein Interactions (158)
CCT6B
Novelty: 0.28933315
p_int: 0.993218455
p_ni: 0.006781544
p_wrong: 1e-9
Data Source: BioPlex
ACACA
Family: Enzyme
Novelty: 0.00248313
p_int: 0.984992108
p_ni: 0.015007892
Data Source: BioPlex
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (31)
Reactome (4)
KEGG (3)
PathwayCommons (4)
WikiPathways (20)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (4)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 3 | 3 | 4 | 90.8 | |||||
hemoglobin measurement | 2 | 3 | 3 | 89.1 | |||||
ferritin measurement | 1 | 1 | 1 | 82.7 | |||||
intraocular pressure measurement | 1 | 1 | 1 | 33.1 | |||||
reasoning | 1 | 1 | 0 | 1.7 | 17.8 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 4 | 90.8 | |||||
hemoglobin measurement | 3 | 89.1 | |||||
ferritin measurement | 1 | 82.7 | |||||
intraocular pressure measurement | 1 | 33.1 | |||||
reasoning | 0 | 1.7 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | egl-9 family hypoxia inducible factor 3 | VGNC:10306 | 452850 | |||||
Macaque | egl-9 family hypoxia inducible factor 3 | 717342 | ||||||
Mouse | MGI:1932288 | 112407 | ||||||
Rat | RGD:71019 | 54702 | ||||||
Dog | egl-9 family hypoxia inducible factor 3 | VGNC:40241 | 480286 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | egl-9 family hypoxia inducible factor 3 | |||||
Macaque | egl-9 family hypoxia inducible factor 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | egl-9 family hypoxia inducible factor 3 | |||||
Publication Statistics
PubMed Score 170.16
PubMed score by year
PubTator Score 110.98
PubTator score by year
Related Publications
Text Mined References (91)
GeneRif Annotations (68)
Items per page:
0 of 0
PMID | Year | Title |
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