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Tbio
EGFL6
Epidermal growth factor-like protein 6

Protein Summary
Description
May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361306
  • ENSP00000355126
  • ENSG00000198759
  • ENST00000380602
  • ENSP00000369976

Symbol
  • MAEG
  • W80
  • MAEG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.85
cell type or tissue
0.73
PubMedID
0.67
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.999992463
p_ni:  0.000007537
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.999748589
p_ni:  0.000251411
Score:  0.162
Data Source:  BioPlex,STRINGDB
ALG13
Tbio
Family:  Enzyme
Novelty:  0.04054611
p_int:  0.997988801
p_ni:  0.002011199
Score:  0.219
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.997668003
p_ni:  0.002331997
Score:  0.153
Data Source:  BioPlex,STRINGDB
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.995911002
p_ni:  0.004088998
Score:  0.172
Data Source:  BioPlex,STRINGDB
HDGF
Tbio
Family:  Epigenetic
Novelty:  0.00273227
p_int:  0.971171782
p_ni:  0.028828218
Score:  0.319
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.910445733
p_ni:  0.089554267
Score:  0.209
Data Source:  BioPlex,STRINGDB
FAM8A1
Tbio
Novelty:  0.08206001
p_int:  0.841980373
p_ni:  0.158019627
Data Source:  BioPlex
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
p_int:  0.840301289
p_ni:  0.159698711
Score:  0.798
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.818064768
p_ni:  0.181935232
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
44.2
monocyte percentage of leukocytes
1
1
1
29
neutrophil count
1
1
1
10.9
leukocyte count
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
44.2
monocyte percentage of leukocytes
1
29
neutrophil count
1
10.9
leukocyte count
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EGF like domain multiple 6
VGNC:7457
473523
Mouse
MGI:1858599
54156
Rat
RGD:1563321
317470
Dog
EGF like domain multiple 6
VGNC:40236
491745
Horse
EGF like domain multiple 6
VGNC:17457
100054915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EGF like domain multiple 6
Mouse
Rat
Dog
EGF like domain multiple 6
Horse
EGF like domain multiple 6
Publication Statistics
PubMed Score 32.58
PubMed score by year
PubTator Score 16.68
PubTator score by year
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Related Publications
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PMID
Year
Title