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Tbio
EFR3B
Protein EFR3 homolog B

Protein Summary
Description
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401432
  • ENSP00000386082
  • ENSG00000084710
  • ENST00000403714
  • ENSP00000384081
  • ENST00000405108
  • ENSP00000384454

Symbol
  • KIAA0953
  • KIAA0953
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
transcription factor perturbation
0.74
cell type or tissue
0.68
histone modification site profile
0.64
microRNA
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999990898
p_ni:  0.000009066
p_wrong:  3.6e-8
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.959561012
p_ni:  0.000575193
p_wrong:  0.039863795
Data Source:  BioPlex
FCAR
Tbio
Novelty:  0.00436414
p_int:  0.956064234
p_ni:  0.000042192
p_wrong:  0.043893574
Score:  0.517
Data Source:  BioPlex,STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.911429528
p_ni:  0.000392186
p_wrong:  0.088178286
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.893585546
p_ni:  0.000060521
p_wrong:  0.106353933
Data Source:  BioPlex
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
p_int:  0.888675598
p_ni:  0.001644681
p_wrong:  0.10967972
Score:  0.189
Data Source:  BioPlex,STRINGDB
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.888675598
p_ni:  0.001644681
p_wrong:  0.10967972
Data Source:  BioPlex
TTC7A
Tbio
Novelty:  0.0282236
Score:  0.854
Data Source:  STRINGDB
TTC7B
Tbio
Novelty:  0.22257455
Score:  0.842
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.826
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
14
15
96.1
waist-hip ratio
4
9
9
92.3
body height
3
2
3
91.5
BMI-adjusted hip circumference
2
10
11
91.4
BMI-adjusted waist-hip ratio
2
7
7
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
15
96.1
waist-hip ratio
9
92.3
body height
3
91.5
BMI-adjusted hip circumference
11
91.4
BMI-adjusted waist-hip ratio
7
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EFR3 homolog B
VGNC:316
459073
Macaque
EFR3 homolog B
693990
Mouse
MGI:2444851
668212
Rat
RGD:1310845
313928
Dog
EFR3 homolog B
VGNC:40232
475686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EFR3 homolog B
Macaque
EFR3 homolog B
Mouse
Rat
Dog
EFR3 homolog B
Publication Statistics
PubMed Score 2.43
PubMed score by year
PubTator Score 0.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title