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Tbio
EFR3A
Protein EFR3 homolog A

Protein Summary
Description
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254624
  • ENSP00000254624
  • ENSG00000132294
  • ENST00000519656
  • ENSP00000428086

Symbol
  • KIAA0143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
disease perturbation
0.9
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.998741395
p_ni:  0.001258585
p_wrong:  2e-8
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.99825951
p_ni:  0.001740481
p_wrong:  8e-9
Data Source:  BioPlex
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.995196928
p_ni:  0.004803072
Data Source:  BioPlex
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.992087085
p_ni:  0.007912915
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.989145941
p_ni:  0.010854058
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.985932975
p_ni:  0.014066707
p_wrong:  3.18e-7
Data Source:  BioPlex
VPS4B
Tchem
Novelty:  0.00788708
p_int:  0.978242895
p_ni:  0.020360284
p_wrong:  0.001396821
Score:  0.312
Data Source:  BioPlex,STRINGDB
MMP26
Tchem
Family:  Enzyme
Novelty:  0.02180874
p_int:  0.96697463
p_ni:  0.033024097
p_wrong:  0.000001273
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.964132224
p_ni:  0.035867675
p_wrong:  1e-7
Data Source:  BioPlex
ZNF517
Tdark
Family:  TF
Novelty:  1.60617003
p_int:  0.963375301
p_ni:  0.036624179
p_wrong:  5.2e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
5.2
1
1
0
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
5.2
0
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EFR3 homolog A
VGNC:885
464402
Macaque
EFR3 homolog A
696036
Mouse
MGI:1923990
76740
Rat
RGD:1305976
362923
Dog
EFR3 homolog A
VGNC:40231
475102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EFR3 homolog A
Macaque
EFR3 homolog A
Mouse
Rat
Dog
EFR3 homolog A
Publication Statistics
PubMed Score 8.55
PubMed score by year
PubTator Score 2.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title