Tbio EFNB1 Ephrin-B1

Protein Summary

Description

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P98172
• D3DVU0

Gene Name

• EFNB1

Ensembl ID

• ENST00000204961
• ENSP00000204961
• ENSG00000090776

Symbol

• EFL3
• EPLG2
• LERK2
• CFND
• CFNS
• EFB1
• EFL3
• EPLG2
• Elk-L
• LERK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
kinase perturbation	0.76
cell type or tissue	0.71
disease	0.65
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Ephrin-b1

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Ephrin-b1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.28   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 517   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.28   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0