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Tbio
EFNA5
Ephrin-A5

Protein Summary
Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333274
  • ENSP00000328777
  • ENSG00000184349

Symbol
  • EPLG7
  • LERK7
  • AF1
  • EFL5
  • RAGS
  • EPLG7
  • GLC1M
  • LERK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.84
gene perturbation
0.83
PubMedID
0.82
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1048.97   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1048.97   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (201)
EPHA5
Tchem
Family:  Kinase
Novelty:  0.01143252
p_int:  0.999997399
p_ni:  3.11e-7
p_wrong:  0.00000229
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAP1
Tbio
Novelty:  0.02264011
p_int:  0.999994811
p_ni:  0.000005189
Data Source:  BioPlex
TAP2
Tbio
Novelty:  0.0390555
p_int:  0.999989092
p_ni:  0.000010908
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999950956
p_ni:  0.000049044
Data Source:  BioPlex
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.999947839
p_ni:  0.000052161
Score:  0.998
Data Source:  BioPlex,STRINGDB
EPHA6
Tchem
Family:  Kinase
Novelty:  0.02713974
p_int:  0.999903155
p_ni:  0.000096842
p_wrong:  2e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
EPHA3
Tchem
Family:  Kinase
Novelty:  0.00466013
p_int:  0.999878385
p_ni:  0.000121615
Score:  0.999
Data Source:  BioPlex,STRINGDB
EPHA8
Tchem
Family:  Kinase
Novelty:  0.02244256
p_int:  0.999797375
p_ni:  0.000202533
p_wrong:  9.3e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.999418723
p_ni:  0.000581277
Score:  0.999
Data Source:  BioPlex,STRINGDB
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.997568562
p_ni:  0.002431438
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (31)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
6
7
95.3
self reported educational attainment
3
4
4
92.1
educational attainment
1
8
8
83
mathematical ability
3
4
5
69.9
smoking status measurement
2
1
2
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
95.3
self reported educational attainment
4
92.1
educational attainment
8
83
mathematical ability
5
69.9
smoking status measurement
2
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ephrin A5
VGNC:11937
471594
Macaque
ephrin A5
704351
Mouse
MGI:107444
13640
Rat
RGD:620391
116683
Dog
ephrin A5
VGNC:53168
608458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ephrin A5
Macaque
ephrin A5
Mouse
Rat
Dog
ephrin A5
Publication Statistics
PubMed Score 1048.97
PubMed score by year
PubTator Score 236.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title