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Tbio
EFHC2
EF-hand domain-containing family member C2

Protein Summary
Description
This gene encodes a protein which contains three DM10 domains and three calcium-binding EF-hand motifs. A related protein is encoded by a gene on chromosome 6. It has been suggested that both proteins are involved in the development of epilepsy (PMID: 15258581, 16112844) and that this gene may be associated with fear recognition in individuals with Turner syndrome. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420999
  • ENSP00000404232
  • ENSG00000183690

Symbol
  • MRX74
  • dJ1158H2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
histone modification site profile
0.67
microRNA
0.6
gene perturbation
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
GPR82
Tdark
Family:  GPCR
Novelty:  0.39696704
Score:  0.834
Data Source:  STRINGDB
GPR34
Tchem
Family:  GPCR
Novelty:  0.03810628
Score:  0.805
Data Source:  STRINGDB
ARHGEF5
Tbio
Novelty:  0.12603141
Score:  0.727
Data Source:  STRINGDB
BCLAF3
Tdark
Novelty:  1.67603845
Score:  0.727
Data Source:  STRINGDB
GRAMD2A
Tbio
Novelty:  0.4291251
Score:  0.689
Data Source:  STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
Score:  0.647
Data Source:  STRINGDB
GTF2IRD1
Tbio
Family:  TF
Novelty:  0.01858027
Score:  0.64
Data Source:  STRINGDB
FUNDC1
Tbio
Novelty:  0.02333176
Score:  0.618
Data Source:  STRINGDB
PRODH2
Tbio
Family:  Enzyme
Novelty:  0.09377289
Score:  0.608
Data Source:  STRINGDB
RFC2
Tbio
Novelty:  0.02088405
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
10
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921655
74405
Rat
RGD:1563388
302507
Dog
EF-hand domain containing 2
VGNC:40224
480888
Horse
EF-hand domain containing 2
VGNC:17446
100059410
Pig
EF-hand domain containing 2
100622362
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
EF-hand domain containing 2
Horse
EF-hand domain containing 2
Pig
EF-hand domain containing 2
Publication Statistics
PubMed Score 12.56
PubMed score by year
PubTator Score 9.05
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title