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Tbio
EFEMP1
EGF-containing fibulin-like extracellular matrix protein 1

Protein Summary
Description
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355426
  • ENSP00000347596
  • ENSG00000115380
  • ENST00000394555
  • ENSP00000378058

Symbol
  • FBLN3
  • FBNL
  • DHRD
  • DRAD
  • FBNL
  • MLVT
  • MTLV
  • S1-5
  • FBLN3
  • FIBL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
viral protein
0.93
protein domain
0.92
PubMedID
0.89
virus
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.65   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.65   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
ZNF747
Tdark
Novelty:  9
p_int:  0.999998436
p_ni:  0.000001539
p_wrong:  2.5e-8
Data Source:  BioPlex
FBLN2
Tbio
Novelty:  0.01340024
p_int:  0.999996844
p_ni:  0.000003142
p_wrong:  1.3e-8
Score:  0.922
Data Source:  BioPlex,STRINGDB
ZNF628
Tdark
Family:  TF
Novelty:  0.50407457
p_int:  0.999989912
p_ni:  4e-7
p_wrong:  0.000009688
Score:  0.352
Data Source:  BioPlex,STRINGDB
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
p_int:  0.999988712
p_ni:  0.000011278
p_wrong:  1e-8
Data Source:  BioPlex
ZNF627
Tdark
Family:  TF
Novelty:  0.34605017
p_int:  0.999982907
p_ni:  0.000017088
p_wrong:  5e-9
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999981995
p_ni:  4.91e-7
p_wrong:  0.000017514
Data Source:  BioPlex
ZBTB9
Tdark
Novelty:  0.95590016
p_int:  0.999949121
p_ni:  0.000050821
p_wrong:  5.8e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
ZNF358
Tdark
Family:  TF
Novelty:  0.77495044
p_int:  0.999948968
p_ni:  0.000019616
p_wrong:  0.000031416
Score:  0.195
Data Source:  BioPlex,STRINGDB
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.999883278
p_ni:  0.000116722
Data Source:  BioPlex
ZNF316
Tdark
Novelty:  1.0869977
p_int:  0.999777866
p_ni:  0.000222134
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
33
42
98.5
body height
11
5
14
5.8
98.1
BMI-adjusted waist circumference
8
23
41
97.2
vital capacity
2
2
1
21.1
91
white matter hyperintensity measurement
7
3
6
9.1
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
42
98.5
body height
14
5.8
98.1
BMI-adjusted waist circumference
41
97.2
vital capacity
1
21.1
91
white matter hyperintensity measurement
6
9.1
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1339998
216616
Rat
RGD:1308528
305604
Dog
EGF containing fibulin extracellular matrix protein 1
VGNC:40220
474604
Horse
EGF containing fibulin extracellular matrix protein 1
VGNC:17442
100066175
Cow
EGF containing fibulin extracellular matrix protein 1
VGNC:28348
511566
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
EGF containing fibulin extracellular matrix protein 1
Horse
EGF containing fibulin extracellular matrix protein 1
Cow
EGF containing fibulin extracellular matrix protein 1
Publication Statistics
PubMed Score 208.65
PubMed score by year
PubTator Score 130.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title