Tdark EFCAB2 Dynein regulatory complex protein 8

Protein Summary

Description

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q5VUJ9
• B4DZE9
• Q59G23
• Q9BS36

Gene Name

• EFCAB2

Ensembl ID

• ENST00000366522
• ENSP00000355479
• ENSG00000203666
• ENST00000366523
• ENSP00000355480
• ENST00000447569
• ENSP00000408661

Symbol

• DRC8
• DRC8
• CFAP200

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
microRNA	0.97
cellular component	0.84
transcription factor perturbation	0.68
small molecule perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (50)

Explore Interacting Targets

1 – 10 of 50

• See Interactions on String-DB

IQCN

Tdark

Novelty:  2.74045479

p_int:  0.999996816

p_wrong:  0.000003184

Score:  0.228

Data Source:  BioPlex,STRINGDB

PSKH1

Tbio

Family:  Kinase

Novelty:  0.20577182

Score:  0.776

Data Source:  STRINGDB

PGBD5

Tdark

Novelty:  0.15960609

Score:  0.77

Data Source:  STRINGDB

IQCD

Tbio

Novelty:  0.21789956

Score:  0.762

Data Source:  STRINGDB

IQCA1

Tdark

Novelty:  0.33986781

Score:  0.747

Data Source:  STRINGDB

IQCG

Tbio

Novelty:  0.19968917

Score:  0.745

Data Source:  STRINGDB

GIN1

Tbio

Family:  Enzyme

Novelty:  0.0247804

Score:  0.694

Data Source:  STRINGDB

GALNT2

Tchem

Family:  Enzyme

Novelty:  0.02458542

Score:  0.681

Data Source:  STRINGDB

PPEF2

Tbio

Family:  Enzyme

Novelty:  0.18717195

Score:  0.677

Data Source:  STRINGDB

DESI2

Tbio

Family:  Enzyme

Novelty:  0.026329

Score:  0.666

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (3)

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10

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GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	1	1	0	1.8	14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	0	1.8	14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell projection
Cilium
Complete proteome
Cytoplasm
Cytoskeleton
Flagellum
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
colorectal cancer

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	EF-hand calcium binding domain 2	VGNC:1233	469735
Mouse	EF-hand calcium binding domain 2	MGI:1915476	68226
Cow	EF-hand calcium binding domain 2	VGNC:28343	615715
Pig	EF-hand calcium binding domain 2		100515403
Anole lizard	EF-hand calcium binding domain 2		100554898

Species	Name	OMA	EggNOG	Inparanoid
Chimp	EF-hand calcium binding domain 2
Mouse	EF-hand calcium binding domain 2
Cow	EF-hand calcium binding domain 2
Pig	EF-hand calcium binding domain 2
Anole lizard	EF-hand calcium binding domain 2

Publication Statistics

PubMed Score 2.76

PubMed score by year

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PubTator Score 1.38

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (1)

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10

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PMID	Year	Title