You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EEF2K
Eukaryotic elongation factor 2 kinase

Protein Summary
Description
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263026
  • ENSP00000263026
  • ENSG00000103319

Symbol
  • eEF-2K
  • CaMKIII
  • HSU93850
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
transcription factor binding site profile
0.98
transcription factor perturbation
0.88
ligand (protein) perturbation
0.83
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.25   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.25   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (71)
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.999969701
p_ni:  6e-9
p_wrong:  0.000030293
Score:  0.288
Data Source:  BioPlex,STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.997
Data Source:  STRINGDB
RPS6KB1
Tchem
Family:  Kinase
Novelty:  0.00044681
Score:  0.988
Data Source:  Reactome,STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.951
Data Source:  STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
Score:  0.873
Data Source:  STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
Score:  0.87
Data Source:  STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
Score:  0.831
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.817
Data Source:  STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
Score:  0.817
Data Source:  STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
Score:  0.817
Data Source:  STRINGDB
Pathways (12)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
mTOR signalling
Reactome
mTORC1-mediated signalling
Name
Explore in Pharos
Explore in Source
Signal Transduction
mTOR signalling
mTORC1-mediated signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
71.1
body height
1
1
1
42.3
1
1
0
5.8
26.6
age at onset
1
1
0
5.8
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
71.1
body height
1
42.3
0
5.8
26.6
age at onset
0
5.8
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic elongation factor 2 kinase
VGNC:5755
454350
Macaque
eukaryotic elongation factor 2 kinase
698604
Mouse
MGI:1195261
13631
Rat
RGD:2538
25435
Dog
eukaryotic elongation factor 2 kinase
VGNC:40210
479812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic elongation factor 2 kinase
Macaque
eukaryotic elongation factor 2 kinase
Mouse
Rat
Dog
eukaryotic elongation factor 2 kinase
Publication Statistics
PubMed Score 51.25
PubMed score by year
PubTator Score 128.16
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text