Tchem EEF1A1 Elongation factor 1-alpha 1

Protein Summary

Description

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P68104
• P04719
• P04720
• Q6IQ15
• EF-1-alpha-1

Gene Name

• EEF1A1

Ensembl ID

• ENST00000309268
• ENSP00000339053
• ENSG00000156508
• ENST00000316292
• ENSP00000339063
• ENST00000331523
• ENSP00000330054

Symbol

• EEF1A
• EF1A
• LENG7
• CCS3
• EF1A
• PTI1
• CCS-3
• EE1A1
• EEF-1
• EEF1A
• EF-Tu
• LENG7
• eEF1A-1
• GRAF-1EF
• HNGC:16303

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
virus perturbation	1
molecular function	0.99

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Elongation Factor 1-alpha 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor 1-alpha 1

Protein / Hydrolase / Elongation Factor 1-alpha 1

Protein / Enzyme Modulator / G-protein / Elongation Factor 1-alpha 1

DTO Classes

Protein / Enzyme / Hydrolase / Elongation Factor 1-alpha 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1904.49   (req: < 5)

Gene RIFs: 114   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1904.49   (req: >= 5)

Gene RIFs: 114   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0