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Tchem
EEF1A1
Elongation factor 1-alpha 1

Protein Summary
Description
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309268
  • ENSP00000339053
  • ENSG00000156508
  • ENST00000316292
  • ENSP00000339063
  • ENST00000331523
  • ENSP00000330054

Symbol
  • EEF1A
  • EF1A
  • LENG7
  • CCS3
  • EF1A
  • PTI1
  • CCS-3
  • EE1A1
  • EEF-1
  • EEF1A
  • EF-Tu
  • LENG7
  • eEF1A-1
  • GRAF-1EF
  • HNGC:16303
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
virus perturbation
1
molecular function
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1697.03   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1697.03   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (509)
EEF1A2
Tchem
Novelty:  0.001472
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.999999611
p_ni:  3.89e-7
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PBDC1
Tdark
Novelty:  0.79983498
p_int:  0.99999673
p_ni:  0.00000327
Score:  0.869
Data Source:  BioPlex,STRINGDB
TTLL12
Tbio
Family:  Enzyme
Novelty:  0.12652318
p_int:  0.999993662
p_ni:  0.000006338
Score:  0.915
Data Source:  BioPlex,STRINGDB
VARS
Tchem
Family:  Enzyme
Novelty:  0.00720227
p_int:  0.99997119
p_ni:  0.000028809
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
CARS
Tchem
Family:  Enzyme
Novelty:  0.02078279
p_int:  0.99996164
p_ni:  0.00003836
Score:  0.942
Data Source:  BioPlex,STRINGDB
EEF1B2
Tbio
Novelty:  0.00970356
p_int:  0.998380919
p_ni:  0.001619081
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EEF1AKMT1
Tdark
Family:  Enzyme
Novelty:  0.22249584
p_int:  0.996886885
p_ni:  0.003113115
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
EEF1G
Tbio
Novelty:  0.01473013
p_int:  0.995997141
p_ni:  0.004002859
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.976424522
p_ni:  0.023575478
Score:  0.432
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Autophagy (R-HSA-9612973)

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Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chaperone Mediated Autophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Chaperone Mediated Autophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 alpha 1
VGNC:11066
494136
Mouse
MGI:1096881
13627
Rat
RGD:67387
171361
Cow
eukaryotic translation elongation factor 1 alpha 1
282220
Opossum
eukaryotic translation elongation factor 1 alpha 1
100016447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 alpha 1
Mouse
Rat
Cow
eukaryotic translation elongation factor 1 alpha 1
Opossum
eukaryotic translation elongation factor 1 alpha 1
Publication Statistics
PubMed Score 1697.03
PubMed score by year
PubTator Score 419.72
PubTator score by year
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Related Publications
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PMID
Text