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Tbio
EDRF1
Erythroid differentiation-related factor 1

Protein Summary
Description
Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337623
  • ENSP00000336727
  • ENSG00000107938
  • ENST00000356792
  • ENSP00000349244
  • ENST00000368815
  • ENSP00000357805
  • ENST00000419769
  • ENSP00000396544

Symbol
  • C10orf137
  • C10orf137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
histone modification site profile
0.77
kinase perturbation
0.76
cell type or tissue
0.67
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.999999778
p_ni:  2.21e-7
p_wrong:  1e-9
Score:  0.39
Data Source:  BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.999999215
p_ni:  7.85e-7
Data Source:  BioPlex
DNAJB3
Tdark
p_int:  0.999993952
p_ni:  0.000006048
Data Source:  BioPlex
MAB21L1
Tbio
Novelty:  0.07438538
p_int:  0.999973472
p_ni:  0.000026528
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999965527
p_ni:  0.000034472
p_wrong:  1e-9
Data Source:  BioPlex
CPXM2
Tbio
Family:  Enzyme
Novelty:  0.09967229
p_int:  0.999960036
p_ni:  0.000039961
p_wrong:  3e-9
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.999947181
p_ni:  0.000052819
Data Source:  BioPlex
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.99992748
p_ni:  0.000072519
p_wrong:  1e-9
Data Source:  BioPlex
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.99988102
p_ni:  0.000118887
p_wrong:  9.3e-8
Data Source:  BioPlex
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.999831619
p_ni:  0.000168381
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
70.2
appendicular lean mass
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
70.2
appendicular lean mass
1
0.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erythroid differentiation regulatory factor 1
VGNC:3840
736116
Macaque
erythroid differentiation regulatory factor 1
695685
Mouse
MGI:1919831
214764
Rat
RGD:1306820
309069
Dog
erythroid differentiation regulatory factor 1
VGNC:40204
100856332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erythroid differentiation regulatory factor 1
Macaque
erythroid differentiation regulatory factor 1
Mouse
Rat
Dog
erythroid differentiation regulatory factor 1
Publication Statistics
PubMed Score 5.04
PubMed score by year
PubTator Score 5.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title