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Tclin
EDNRB
Endothelin receptor type B

Protein Summary
Description
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334286
  • ENSP00000335311
  • ENSG00000136160
  • ENST00000377211
  • ENSP00000366416
  • ENST00000475537
  • ENSP00000487082
  • ENST00000626030
  • ENSP00000486202
  • ENST00000646605
  • ENSP00000494278
  • ENST00000646607
  • ENSP00000493527
  • ENST00000646948
  • ENSP00000493895

Symbol
  • ETRB
  • ETB
  • ET-B
  • ETB1
  • ETBR
  • ETRB
  • HSCR
  • WS4A
  • ABCDS
  • ET-BR
  • HSCR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.94
kinase perturbation
0.93
gene perturbation
0.9
microRNA
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2493.64   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2493.64   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 267
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4