Protein Summary
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- ENST00000324300
- ENSP00000315011
- ENSG00000151617
- ENST00000358556
- ENSP00000351359
- ENST00000506066
- ENSP00000425281
- ENST00000510697
- ENSP00000427259
- ENST00000511804
- ENSP00000425354
- ENST00000648866
- ENSP00000496976
- ETA
- ETRA
- ETA
- ET-A
- ETAR
- ETRA
- MFDA
- ETA-R
- hET-AR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 0.92 | ||
transcription factor perturbation | 0.84 | ||
chemical | 0.82 | ||
disease | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1978.13 (req: < 5)
Gene RIFs: 147 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1978.13 (req: >= 5)
Gene RIFs: 147 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 831
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (831)
Protein-Protein Interactions (244)
BCL2L11
Novelty: 0.00055914
p_int: 0.994878599
p_ni: 0.005121396
p_wrong: 5e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
MCL1
Novelty: 0.00046181
p_int: 0.980366422
p_ni: 0.019633577
p_wrong: 1e-9
Score: 0.561
Data Source: BioPlex,STRINGDB
MTX1
Novelty: 0.02350764
p_int: 0.97084787
p_ni: 0.02915213
Score: 0.181
Data Source: BioPlex,STRINGDB
ARL5B
Family: Enzyme
Novelty: 0.03703395
p_int: 0.941469891
p_ni: 0.058510427
p_wrong: 0.000019682
Score: 0.19
Data Source: BioPlex,STRINGDB
LMBR1
Novelty: 0.00591824
p_int: 0.902245521
p_ni: 0.096104913
p_wrong: 0.001649566
Score: 0.187
Data Source: BioPlex,STRINGDB
MT-ND1
Family: Enzyme
Novelty: 0.00090183
p_int: 0.875744027
p_ni: 0.097652729
p_wrong: 0.026603245
Score: 0.175
Data Source: BioPlex,STRINGDB
EBP
Family: Enzyme
Novelty: 0.00610658
p_int: 0.861392487
p_ni: 0.137217551
p_wrong: 0.001389961
Score: 0.211
Data Source: BioPlex,STRINGDB
SYNGR2
Novelty: 0.1089664
p_int: 0.860654258
p_ni: 0.13932102
p_wrong: 0.000024722
Score: 0.211
Data Source: BioPlex,STRINGDB
MT-CO1
Family: Enzyme
Novelty: 0.00008262
p_int: 0.798530801
p_ni: 0.201451169
p_wrong: 0.00001803
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (23)
Reactome (7)
KEGG (7)
PathwayCommons (3)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (2)
Components (2)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 5 | 4 | 1.1 | 95.9 | |||||
3 | 3 | 2 | 1.2 | 89.8 | |||||
platelet crit | 2 | 2 | 2 | 88 | |||||
platelet count | 1 | 1 | 1 | 71 | |||||
red blood cell density measurement | 1 | 1 | 1 | 59.6 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
4 | 1.1 | 95.9 | |||||
2 | 1.2 | 89.8 | |||||
platelet crit | 2 | 88 | |||||
platelet count | 1 | 71 | |||||
red blood cell density measurement | 1 | 59.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | endothelin receptor type A | VGNC:594 | 461530 | |||||
Macaque | endothelin receptor type A | 704135 | ||||||
Mouse | MGI:105923 | 13617 | ||||||
Rat | RGD:2535 | 24326 | ||||||
Dog | endothelin receptor type A | VGNC:40202 | 450187 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | endothelin receptor type A | |||||
Macaque | endothelin receptor type A | |||||
Mouse | ||||||
Rat | ||||||
Dog | endothelin receptor type A | |||||
Publication Statistics
PubMed Score 1978.13
PubMed score by year
PubTator Score 2210.99
PubTator score by year
Patents
Patents by year
Related Publications
GeneRif Annotations (147)
Items per page:
0 of 0
PMID | Text |
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