Protein Summary
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- ENST00000324300
- ENSP00000315011
- ENSG00000151617
- ENST00000358556
- ENSP00000351359
- ENST00000506066
- ENSP00000425281
- ENST00000510697
- ENSP00000427259
- ENST00000511804
- ENSP00000425354
- ENST00000648866
- ENSP00000496976
- ETA
- ETRA
- ETA
- ET-A
- ETAR
- ETRA
- MFDA
- ETA-R
- hET-AR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 0.92 | ||
transcription factor perturbation | 0.84 | ||
chemical | 0.82 | ||
disease | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2413.55 (req: < 5)
Gene RIFs: 147 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2413.55 (req: >= 5)
Gene RIFs: 147 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 828
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5