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Tclin
EDNRA
Endothelin-1 receptor

Protein Summary
Description
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324300
  • ENSP00000315011
  • ENSG00000151617
  • ENST00000358556
  • ENSP00000351359
  • ENST00000506066
  • ENSP00000425281
  • ENST00000510697
  • ENSP00000427259
  • ENST00000511804
  • ENSP00000425354
  • ENST00000648866
  • ENSP00000496976

Symbol
  • ETA
  • ETRA
  • ETA
  • ET-A
  • ETAR
  • ETRA
  • MFDA
  • ETA-R
  • hET-AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.92
transcription factor perturbation
0.84
chemical
0.82
disease
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2413.55   (req: < 5)
Gene RIFs: 147   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2413.55   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 828
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5