Protein Summary
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- ENST00000379375
- ENSP00000368683
- ENSG00000078401
- ET1
- QME
- PPET1
- ARCND3
- HDLCQ7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
PubMedID | 1 | ||
gene perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15477.05 (req: < 5)
Gene RIFs: 789 (req: <= 3)
Antibodies: 741 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15477.05 (req: >= 5)
Gene RIFs: 789 (req: > 3)
Antibodies: 741 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 100
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0