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Tbio
EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

Protein Summary
Description
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318130
  • ENSP00000318147
  • ENSG00000116406
  • ENST00000367512
  • ENSP00000356482

Symbol
  • C1orf22
  • C1orf22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
pathway
0.8
microRNA
0.67
transcription factor binding site profile
0.67
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.81   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.81   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.988110743
p_ni:  0.011889257
Data Source:  BioPlex
ANGPTL7
Tbio
Novelty:  0.03893082
p_int:  0.973389554
p_ni:  0.026610446
Score:  0.228
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.922382135
p_ni:  0.077617865
Score:  0.947
Data Source:  BioPlex,STRINGDB
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.916266959
p_ni:  0.083733041
Data Source:  BioPlex
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
p_int:  0.891863873
p_ni:  0.108136127
Score:  0.187
Data Source:  BioPlex,STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.962
Data Source:  STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
Score:  0.957
Data Source:  STRINGDB
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
Score:  0.949
Data Source:  STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.904
Data Source:  STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
Score:  0.889
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
1
4
84
sex hormone-binding globulin measurement
4
1
4
75.1
alkaline phosphatase measurement
1
1
1
70.4
comparative body size at age 10, self-reported
1
1
1
70.1
educational attainment
1
1
1
68.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
84
sex hormone-binding globulin measurement
4
75.1
alkaline phosphatase measurement
1
70.4
comparative body size at age 10, self-reported
1
70.1
educational attainment
1
68.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER degradation enhancing alpha-mannosidase like protein 3
VGNC:9852
457578
Macaque
ER degradation enhancing alpha-mannosidase like protein 3
714475
Mouse
MGI:1914217
66967
Rat
RGD:1561496
289085
Dog
ER degradation enhancing alpha-mannosidase like protein 3
VGNC:40196
480040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER degradation enhancing alpha-mannosidase like protein 3
Macaque
ER degradation enhancing alpha-mannosidase like protein 3
Mouse
Rat
Dog
ER degradation enhancing alpha-mannosidase like protein 3
Publication Statistics
PubMed Score 13.81
PubMed score by year
PubTator Score 7.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title