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Tbio
EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

Protein Summary
Description
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256497
  • ENSP00000256497
  • ENSG00000134109
  • ENST00000445686
  • ENSP00000394099

Symbol
  • EDEM
  • KIAA0212
  • EDEM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.95
transcription factor perturbation
0.91
virus perturbation
0.88
microRNA
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.06   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.06   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
MSH5
Tbio
Novelty:  0.0109825
p_int:  0.999999162
p_ni:  8.34e-7
p_wrong:  4e-9
Data Source:  BioPlex
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.999994341
p_ni:  0.000005659
Score:  0.177
Data Source:  BioPlex,STRINGDB
OMA1
Tbio
Family:  Enzyme
Novelty:  0.00963387
p_int:  0.999987968
p_ni:  0.000012032
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999979342
p_ni:  0.000020658
Data Source:  BioPlex
LOXL3
Tchem
Family:  Enzyme
Novelty:  0.03895154
p_int:  0.99984134
p_ni:  0.000158625
p_wrong:  3.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.999819462
p_ni:  0.000180534
p_wrong:  5e-9
Data Source:  BioPlex
MTCH1
Tbio
Novelty:  0.12469914
p_int:  0.998884587
p_ni:  0.001115413
Score:  0.416
Data Source:  BioPlex,STRINGDB
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.99704788
p_ni:  0.002951447
p_wrong:  6.73e-7
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.995918964
p_ni:  0.004081036
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.993295852
p_ni:  0.003150199
p_wrong:  0.003553949
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
IRE1alpha activates chaperones
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
50.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER degradation enhancing alpha-mannosidase like protein 1
VGNC:11386
471107
Mouse
MGI:2180139
192193
Rat
RGD:1563633
297504
Dog
ER degradation enhancing alpha-mannosidase like protein 1
VGNC:40194
476547
Horse
ER degradation enhancing alpha-mannosidase like protein 1
VGNC:17418
100059536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER degradation enhancing alpha-mannosidase like protein 1
Mouse
Rat
Dog
ER degradation enhancing alpha-mannosidase like protein 1
Horse
ER degradation enhancing alpha-mannosidase like protein 1
Publication Statistics
PubMed Score 89.06
PubMed score by year
PubTator Score 48.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text