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Tdark
EDDM3B
Epididymal secretory protein E3-beta

Protein Summary
Description
Possible function in sperm maturation. Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326783
  • ENSP00000314810
  • ENSG00000181552

Symbol
  • FAM12B
  • HE3B
  • EP3B
  • HE3B
  • RAM2
  • FAM12B
  • HE3-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.5
cell type or tissue
0.44
chemical
0.41
tissue sample
0.34
disease
0.28


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.67   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.67   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
CEMIP2
Tbio
Novelty:  0.04698236
p_int:  0.99813967
p_ni:  0.001860316
p_wrong:  1.5e-8
Data Source:  BioPlex
CNTNAP1
Tbio
Novelty:  0.00618741
p_int:  0.997684075
p_ni:  0.001944584
p_wrong:  0.00037134
Data Source:  BioPlex
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.997122755
p_ni:  0.002876594
p_wrong:  6.51e-7
Data Source:  BioPlex
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.996962314
p_ni:  0.003037686
Data Source:  BioPlex
ITGA2
Tbio
Novelty:  0.0013482
p_int:  0.996628845
p_ni:  0.003298579
p_wrong:  0.000072576
Data Source:  BioPlex
SEMA3C
Tbio
Novelty:  0.00828813
p_int:  0.995881178
p_ni:  0.003954915
p_wrong:  0.000163907
Data Source:  BioPlex
ITGA7
Tbio
Novelty:  0.01243073
p_int:  0.995787159
p_ni:  0.004212839
p_wrong:  2e-9
Data Source:  BioPlex
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.99570024
p_ni:  0.00429976
Data Source:  BioPlex
SULF2
Tbio
Family:  Enzyme
Novelty:  0.01536228
p_int:  0.990439009
p_ni:  0.009560976
p_wrong:  1.5e-8
Data Source:  BioPlex
NBR1
Tbio
Novelty:  0.00893066
p_int:  0.986531976
p_ni:  0.013081478
p_wrong:  0.000386546
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
angiogenin measurement
2
4
4
93.3
blood protein measurement
4
9
9
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
angiogenin measurement
4
93.3
blood protein measurement
9
92.4
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epididymal protein 3B
VGNC:3441
738611
Macaque
epididymal protein 3B
704471
Mouse
MGI:2684921
219026
Dog
epididymal protein 3B
100687627
Pig
epididymal protein 3B
397204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epididymal protein 3B
Macaque
epididymal protein 3B
Mouse
Dog
epididymal protein 3B
Pig
epididymal protein 3B
Publication Statistics
PubMed Score 10.67
PubMed score by year
PubTator Score 23.82
PubTator score by year
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Related Publications
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PMID
Year
Title