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Tdark
EDDM3A
Epididymal secretory protein E3-alpha

Protein Summary
Description
Possible function in sperm maturation. Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326842
  • ENSP00000315098
  • ENSG00000181562

Symbol
  • FAM12A
  • HE3A
  • EP3A
  • HE3A
  • RAM1
  • FAM12A
  • HE3ALPHA
  • HE3-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.44
cell line
0.42
microRNA
0.35
disease perturbation
0.31


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CMC1
Tdark
Novelty:  5.14727585
p_int:  0.999999353
p_ni:  2.97e-7
p_wrong:  3.5e-7
Data Source:  BioPlex
B4GALT6
Tbio
Family:  Enzyme
Novelty:  0.08523889
p_int:  0.997672494
p_ni:  0.002301584
p_wrong:  0.000025922
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.995919555
p_ni:  0.004080445
Data Source:  BioPlex
CEMIP2
Tbio
Novelty:  0.04698236
p_int:  0.995375794
p_ni:  0.004623611
p_wrong:  5.95e-7
Data Source:  BioPlex
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.990294774
p_ni:  0.009705226
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
p_int:  0.985368131
p_ni:  0.014626155
p_wrong:  0.000005714
Data Source:  BioPlex
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.964607803
p_ni:  0.035392189
p_wrong:  8e-9
Data Source:  BioPlex
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.961087059
p_ni:  0.038912941
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.957585917
p_ni:  0.04241408
p_wrong:  3e-9
Data Source:  BioPlex
PLTP
Tbio
Novelty:  0.00267612
p_int:  0.956449028
p_ni:  0.038348258
p_wrong:  0.005202714
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epididymal protein 3A
VGNC:12626
738510
Rat
RGD:631349
290032
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epididymal protein 3A
Rat
Publication Statistics
PubMed Score 18.68
PubMed score by year
PubTator Score 11.89
PubTator score by year
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Related Publications
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PMID
Year
Title