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Tbio
EDC4
Enhancer of mRNA-decapping protein 4

Protein Summary
Description
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358933
  • ENSP00000351811
  • ENSG00000038358

Symbol
  • HEDLS
  • GE1
  • Ge-1
  • RCD8
  • HEDL5
  • HEDLS
  • RCD-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.99
transcription factor binding site profile
0.74
disease perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.09   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.09   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999981802
p_ni:  0.000018198
Score:  0.172
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.999954055
p_ni:  0.000045945
Score:  0.999
Data Source:  BioPlex,STRINGDB
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
p_int:  0.999881571
p_ni:  0.000118429
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.997564023
p_ni:  0.002435977
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.987474792
p_ni:  0.012525208
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.983481528
p_ni:  0.016518472
Data Source:  BioPlex
C4orf3
Tbio
Novelty:  0.05950373
p_int:  0.971789438
p_ni:  0.028210562
Data Source:  BioPlex
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.970232267
p_ni:  0.029767733
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.962979188
p_ni:  0.037020812
Data Source:  BioPlex
ANKLE2
Tbio
Novelty:  0.0995907
p_int:  0.962975703
p_ni:  0.037024297
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
20
38
10
99.5
apolipoprotein A 1 measurement
2
5
5
98.4
hemoglobin measurement
3
3
3
92.7
stem Cell Factor measurement
1
2
2
92.4
hematocrit
3
3
3
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
10
99.5
apolipoprotein A 1 measurement
5
98.4
hemoglobin measurement
3
92.7
stem Cell Factor measurement
2
92.4
hematocrit
3
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of mRNA decapping 4
VGNC:5754
454178
Macaque
enhancer of mRNA decapping 4
701393
Mouse
MGI:2446249
234699
Rat
RGD:1562009
361399
Dog
enhancer of mRNA decapping 4
VGNC:40193
489751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of mRNA decapping 4
Macaque
enhancer of mRNA decapping 4
Mouse
Rat
Dog
enhancer of mRNA decapping 4
Publication Statistics
PubMed Score 280.09
PubMed score by year
PubTator Score 63.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title